A two-stage cardiac PET and late gadolinium enhancement MRI co-registration method for improved assessment of non-ischemic cardiomyopathies using integrated PET/MR

Abstract

PurposeRespiratory motion causes mismatches between PET images of the myocardium and the corresponding cardiac MR images in cardiac integrated PET/MR. The mismatch may affect the attenuation correction and the diagnosis of non-ischemic cardiomyopathies. In this study, we present a two-stage cardiac PET and MR Late Gadolinium Enhancement (LGE) co-registration method, which seeks to improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration using an integrated wholebody PET/MR system. MethodsThe proposed PET and LGE two-stage co-registration method was evaluated through comparison with one-stage direct co-registration and no-registration. One hundred and ninety-one slices of LGE and forty lesions were studied. Two trained nuclear medicine physicians independently assessed the displacement between LGE and PET to qualitatively evaluate the co-registration quality. The changes of the mean SUV in the normal myocardium and the LGE-enhanced lesions before and after image co-registration were measured to quantitatively evaluate the accuracy and value of image co-registration. ResultsThe two-stage method had an improved image registration score (4.93±0.89) compared with the noregistration method (3.49±0.84, p value <0.001) and the single-stage method (4.23±0.81, p value <0.001).Furthermore, the two-stage method led to increased SUV value in the myocardium (3.87±2.56) compared with the no-registration method (3.14±1.92, p value <0.001) and the single-stage method (3.32±2.16, p value <0.001). The mean SUV in the LGE lesion signi cantly increased from 2.51±2.09 to 2.85±2.35 (p value<0.001) after the two-stage co-registration. ConclusionThe proposed two-stage registration method signi cantly improved the co-registration between PET andLGE in integrated PET/MR imaging. The technique may improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration.Registered No.

Cerebral hypometabolism mediates the effect of stroke volume on cognitive impairment in heart failure patients

“…There were no significant differences in sex, age, education, BMI, hypertension, diabetes mellitus, hyperlipidaemia, and blood glucose level between the two groups. The cognitive scores of HF patients were lower than in normal controls [MMSE: 27 (24,29) vs. 29 (29,30), P < 0.001; MoCA: 21 (19,26) vs. 26 (25,28), P < 0.001]. The differences of psychiatric rating scales between the two groups were not significant.…”

“…The SUVR images were obtained with pons as the reference region. CMR parameters related to left ventricular structure and function, including end‐diastolic volume (EDV), end‐systolic volume (ESV), stroke volume (SV), left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI), left ventricular mass (LVM), EDV index (EDVI), ESV index, and SV index (SVI), were calculated 19 . The volume and extent of LGE were also measured.…”

“…CMR parameters related to left ventricular structure and function, including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac index (CI), left ventricular mass (LVM), EDV index (EDVI), ESV index, and SV index (SVI), were calculated. 19 The volume and extent of LGE were also measured. The detailed processes of image processing and CMR analysis are presented in Supporting Information, Methods S1.…”

State-of-the-art of nuclear medicine and molecular imaging in China: after the first 66 years (1956–2022)

“…According to the standard EJNMMI list of topics, these research articles were divided into the following categories: advanced image analyses [ 11 – 13 ], preclinical imaging [ 14 – 26 ], translational research [ 27 – 30 ], neurology [ 31 , 32 ], cardiology [ 33 ], and oncology [ 34 – 47 ]. Due to the large number of accepted manuscripts, which is significantly more than the typical number of articles per EJNMMI issue, many invited contributions were published in various issues before this EJNMMI special issue, which include 2 review articles [ 48 , 49 ], many research articles [ 50 – 62 ], and 1 invited editorial [ 63 ].…”