A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Zhang, Jing; Wang, Ningning; Li, Qian; Zhou, Yaxin; Luan, Yuxia

doi:10.1039/d0cc08162k

Cited by 104 publications

(53 citation statements)

References 20 publications

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“…Based on the above situation, a new drug delivery system (DDS) is proposed, which can slowly and continuously release the drug or keep the drug at a constant release rate, and finally deliver the drug to the target location in the body (Patil et al, 2018 ; Zhou et al, 2020 ). Compared with traditional administration methods, DDS can prolong the therapeutic effect of drugs, reduce the number of medications, improve patient compliance, and reduce the systemic side effects of drugs (Ozeki et al, 2012 ; Wen et al, 2013 ; Prajapati et al, 2015 ; Liang et al, 2020 ; Malakinezhad et al, 2020 ; Ren et al, 2021 ; Tian et al, 2021 ; Zhang et al, 2021 ). At present, there are many kinds of new drug delivery systems, microsphere is one of the most common DDS.…”

Section: Introductionmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

220

106

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Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

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Section: Introductionmentioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

220

106

View full text Add to dashboard Cite

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“…Chemotherapy (using antitumor drugs) is one of the most common methods for treatment of various types of cancers, including breast cancer. [ 3 ] Amongst different types of antitumor drugs, paclitaxel (PTX) is a commonly used anticancer drug indicating activity against a wide variety of tumors including lung, ovarian, bladder, and metastatic breast cancer. [ 4,5 ] PTX has been considered as the most significant progress in tumor chemotherapy in recent decades according to the National Cancer Institute (NCI).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Drug‐Loaded Graphene Oxide‐Based Nanocarrier into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer

Asgari

Pourjavadi

Setayeshmehr

et al. 2021

Macro Chemistry & Physics

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With the high rate of mortality associated with breast cancer among women, breast cancer treatment has attracted great deal of attention globally. To reduce the exposure of body organs to high cytotoxicity of the common chemotherapeutic drugs, local co‐delivery of selected chemotherapeutics has emerged as a solution. In this work, an electrospun composite including a co‐drug‐loaded graphene oxide‐based nanocarrier is fabricated for local anticancer applications. To increase dispersion and cellular uptake of graphene oxide (GO), first, the hydroxyl groups at the edges of GO are grafted by poly (epichlorohydrin) (PCH) to form GO‐PCH. Then, the hydroxyl end groups of PCH are grafted (g) with hyperbranched polyglycerol (HPG) leading to formation of oxygen‐rich nanocarrier (GO‐PCH‐g‐HPG). Paclitaxel (PTX) and curcumin (Cur) are loaded into the GO‐PCH‐g‐HPG nanocarrier, and are encapsulated into pullulan nanofibers using electrospinning. SEM, FTIR, and UV–Vis characterizations confirmed the presence and distribution of the nanocarrier inside the nanofibers. The drugs showed a sustained release (93 h) from the nanocarrier‐loaded nanofibers in the neutral pH (7.4). According to MTT assay and optical microscopy, a synergistic cytotoxicity effect of PTX and Cur is observed. The nanocarrier‐encapsulated nanofiber system represents a novel tunable drug delivery system for local chemotherapeutic applications.

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“…The field of nanomedicine has been rapidly expanding over the past decades [ 1 , 2 , 3 ], and liposomes were the first to reach the clinical application stage. The parenteral liposomal drug products currently on the market focus on the treatment of cancer through local delivery of chemotherapeutic drugs [ 4 ], fungal infections through local delivery of the antifungal drug amphotericin B [ 5 ], or pain management through prolonged epidural delivery of morphine [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy

et al. 2021

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Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to (passively) target sites of inflammation and release their content to inflammatory target cells enables them to increase local efficacy with only limited systemic exposure and adverse effects. Nonetheless, few liposomal formulations seem to reach the clinic. The current review provides an overview of the more recent innovations in liposomal treatment of rheumatoid arthritis, psoriasis, vascular inflammation, and transplantation. Cutting edge developments include the liposomal delivery of gene and RNA therapeutics and the use of hybrid systems where several liposomal bilayer features, or several drugs, are combined in a single formulation. The majority of the articles reviewed here focus on preclinical animal studies where proof-of-principle of an improved efficacy–safety ratio is observed when using liposomal formulations. A few clinical studies are included as well, which brings us to a discussion about the challenges of clinical translation of liposomal nanomedicines in the field of inflammatory diseases.

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A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Abstract: A two-pronged approach combining photodynamic therapy and blockade of epithelial–mesenchymal transition in a minimalist nanoplatform was proposed to combat metastasis of basal-like breast cancer.

Cited by 104 publications

References 20 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Encapsulation of Drug‐Loaded Graphene Oxide‐Based Nanocarrier into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy

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