“…Among these, light-triggered drug delivery systems (DDSs) are more superior since the release of drug can be modulated by simply adjusting the wavelength, intensity, or time of exposure of light to attain high-precision spatiotemporal control over the process . To date, different light-responsive DDSs have been developed using well-known photocleavable groups such as o -nitrobenzyl, ,, coumarinyl, ,, anthracenyl, quinolinyl, , p -hydroxyphenacyl, , and o -hydroxycinnamate. , Within these, coumarinyl-, , p -hydroxyphenacyl-, and o -hydroxycinnamate-based systems have gained more traction due to their two-photon phototriggering capability. In the past few years, researchers have demonstrated o -hydroxycinnamate platforms for the uncaging of alcohols with real-time monitoring using one- and two-photon irradiation. ,, The groups of Zhang and Wang have reported an o -hydroxycinnamate-based theranostic prodrug system for tumor selected controlled release of anticancer drugs triggered by hypoxia (internal stimuli) and UV-light (external stimuli) .…”