A two-phase gradual silver release mechanism from a nanostructured TiAlV surface as a possible antibacterial modification in implants

Antibacterial Biomaterials in Orthopedics

“…The e orts are targeted at conceiving new biomaterial with the inherent antibacterial per ormance or on improving the per ormance o biomaterial sur aces through the bactericidal or bacteria-repellent coating. Techniques such as nanostructured topographies that induce bactericidal e ects through cell wall rupture are also being experimented with and o er signi icant potential as an alternative to chemically active sur aces [24][25][26]. This paper is intended to introduce various emerging antibacterial techniques that can be adopted to reduce orthopaedic implant in ection.…”

Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

“…The silver ions released by the silver NPs are highly mobile, and their entrance into living cells with high concentrations can kill healthy cells ( AshaRani et al, 2009 ). The silver element forms which served as antibacterial are Ag2O NPs ( Chen et al, 2017 ; Sarraf et al, 2018a ; Lv et al, 2019 ) and Ag NPs ( Cheng et al, 2019 ; Pruchova et al, 2019 ; Surmeneva et al, 2019 ). The silver NPs that were loaded on the surface of the titanium substrate to produce NS, showing different antibacterial effects and performance that is listed in Table 3 .…”

Biofunctional Elements Incorporated Nano/Microstructured Coatings on Titanium Implants with Enhanced Osteogenic and Antibacterial Performance

“…The AgNPs filled at the openings of the nanotubes release relatively fast while the AgNPs anchored inside the cavities release gradually. [ 173 ] In the study of combined application of AgNPs and antibiotics, the antibacterial efficiency toward common pathogenic bacteria including antibiotic‐resistant bacteria is enhanced and the antibiotic administration period can be shortened from 4 to 3 weeks. [ 48 ] The HA, chitosan, and dialdehyde alginate have been coated on the Ag‐NTs surface to protect the tissue surrounding from the direct contact with Ag without hindering the antibacterial properties of the implant.…”