A two-generation inhalation reproductive toxicity study upon the exposure to manganese chloride

McGough, Doreen; Jardine, Lynne

doi:10.1016/j.neuro.2016.09.017

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Some research has reported that Mn was toxic to the brain−pituitary−testicular axis in rats; however, other research suggested that soluble and insoluble forms of inorganic Mn compounds, by extrapolation, cannot be considered reproductive toxicants. 37,38 These results suggest that the decrease in Zn, Mg, and Mn may also participate in follicle maturation. Furthermore, the concentration changes of other metals, including Fe, Cr, Cd, Si, and As, had no relationship with the FPM and therefore may not be influenced by gasoline and diesel FPM (Figure S3).…”

Section: Environmental Science and Technology Lettersmentioning

confidence: 82%

“…Mn may have complex regulation effects on the ovary. Some research has reported that Mn was toxic to the brain–pituitary–testicular axis in rats; however, other research suggested that soluble and insoluble forms of inorganic Mn compounds, by extrapolation, cannot be considered reproductive toxicants. , These results suggest that the decrease in Zn, Mg, and Mn may also participate in follicle maturation.…”

Section: Results and Discussionmentioning

confidence: 98%

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Fuel Fine Particulate Matter Induces Ovary Dysfunction via Metal Elements Imbalance and Steroid Biosynthesis Signaling Pathway Inhibition

Xia

Zhang

et al. 2018

Environ. Sci. Technol. Lett.

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Fuel fine particulate matter (FPM) is an important component of ambient pollution, has wide biological activity, and can cause a variety of diseases. Epidemiological studies have reported that FPM can decrease human fertility rates, retard embryonic growth, cause adverse effects on pregnancy outcomes, and result in male reproductive damage. However, the effects of FPM on female ovary function and associated mechanisms are still unclear. In this research, different concentrations of gasoline and diesel FPM were chosen to treat female mice in vivo. Fuel FPM can significantly inhibit ovarian function and follicle maturation. The hypothalamus–pituitary–ovary axis was inhibited significantly, with an increase in follicle-stimulating hormone and luteinizing hormone levels and a decrease in estradiol levels, as well as ovary weight loss, which was similar to the symptoms of premature ovarian failure in humans. Fuel FPM can induce the accumulation of copper and lead in the ovary and decrease the levels of zinc, magnesium, and manganese. Simultaneously, the steroid biosynthesis signaling pathway was downregulated, which can contribute to ovarian dysfunction. This study provided a new perspective for understanding the ovarian toxicity of fuel FPM and associated mechanisms, which will aid in the development of new methods to treat ovarian dysfunction induced by FPM.

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Section: Environmental Science and Technology Lettersmentioning

confidence: 82%

Section: Results and Discussionmentioning

confidence: 98%

Fuel Fine Particulate Matter Induces Ovary Dysfunction via Metal Elements Imbalance and Steroid Biosynthesis Signaling Pathway Inhibition

Xia

Zhang

et al. 2018

Environ. Sci. Technol. Lett.

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“…The information drawn in terms of reproduction and fertility has typically been formulated for experimental use and analysis, particularly assessing methods of inhalation of manganese dichloride in rat models, though conclusions are promising to have negative effects on reprotoxicity [ 228 ]. This having been said, more animals’ studies further enhance the association on reproductive hormones, gonadotropin-releasing hormone (GnRH), and FSH expression significant increases in breeder broiler hens [ 229 ].…”

Section: Trace Elements and Female Reproductive Organsmentioning

confidence: 99%

Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers—A State-of-the-Art Review

et al. 2021

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Gynecological neoplasms pose a serious threat to women’s health. It is estimated that in 2020, there were nearly 1.3 million new cases worldwide, from which almost 50% ended in death. The most commonly diagnosed are cervical and endometrial cancers; when it comes to infertility, it affects ~48.5 million couples worldwide and the number is continually rising. Ageing of the population, environmental factors such as dietary habits, environmental pollutants and increasing prevalence of risk factors may affect the reproductive potential in women. Therefore, in order to identify potential risk factors for these issues, attention has been drawn to trace elements. Trace mineral imbalances can be caused by a variety of causes, starting with hereditary diseases, finishing with an incorrect diet or exposure to polluted air or water. In this review, we aimed to summarize the current knowledge regarding trace elements imbalances in the case of gynecologic cancers as well as female fertility and during pregnancy.

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“…In addition, serum Mn excess induces significant changes in testes histology and physiology, and cause seminiferous tubule degeneration (Gabrielsen & Tanrikut, 2016;McGough & Jardine, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of an Organic Trace Mineral Premix on the Semen Quality, Testicular Morphology and Gene Expression Related to Testosterone Synthesis of Male Broiler Breeders

Shan

Dai

Zhu

et al. 2017

Rev. Bras. Cienc. Avic.

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In order to investigate the effect of organic trace minerals premix (OTM) on the reproductive performance of breeder roosters, a total of 240 San Huang roosters (23 weeks of age) were randomly divided into two treatments with six replicates of 20 roosters each. The first group (n = 120) was fed a basal diet containing an inorganic trace minerals premix (ITM) and the other group (n = 120) was fed the basal diet in which ITM was replaced by OTM. The experiment period was 22 weeks. Semen from one randomly-selected rooster per replicate was collected two weeks after the beginning of the experiment and other 10 times every two weeks. Another rooster per replicate was randomly selected at 30, 35, and 45 weeks of age, and sacrificed. Results showed that OTM did not affect relative organ weights. There was a significant increase in semen parameters in OTM group (p<0.05), such as semen volume, semen density, and semen motility from 31 to 35 weeks. OTMfed roosters presented higher serum testosterone levels at 45 weeks of age, as well as higher testicular mRNA expression of the genes 3-beta dehydrogenase 2 (HSD3B2) and cytochrome P450 17A1 (CYP17A1) in the OTM-fed group at 45 weeks of age compared with those fed ITM (p<0.05). Considering the results of the present study, it was concluded that feeding organic instead of inorganic trace minerals to male broilers breeders improves semen quality, which may be attributed to their better testicular development and higher expression of enzymes related to testosterone synthesis.

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A two-generation inhalation reproductive toxicity study upon the exposure to manganese chloride

Cited by 11 publications

References 19 publications

Fuel Fine Particulate Matter Induces Ovary Dysfunction via Metal Elements Imbalance and Steroid Biosynthesis Signaling Pathway Inhibition

Fuel Fine Particulate Matter Induces Ovary Dysfunction via Metal Elements Imbalance and Steroid Biosynthesis Signaling Pathway Inhibition

Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers—A State-of-the-Art Review

Effect of an Organic Trace Mineral Premix on the Semen Quality, Testicular Morphology and Gene Expression Related to Testosterone Synthesis of Male Broiler Breeders

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