A two-component charge transfer hydrogel with excellent sensitivity towards the microenvironment: a responsive platform for biogenic thiols

Abstract

A two-component charge transfer (CT) hydrogel has been derived from supramolecular heteroassembly of a pyrene amino acid conjugate (PyHisOH, donor) with a 4-Chloro-7-nitrobenzofurazan (NBD-Ox, acceptor) derivative in the aqueous medium....

An Amino Acid‐Based Thixotropic Hydrogel: Tuning of Gel Recovery Time by Mechanical Shaking

“…These stimuli are the key ingredients for controlling the self‐assembly behavior of the hydrogelator [15–17] . The stimuli responsive property of hydrogel structure [18–21] is frequently installed into artificial hydrogel system to carry out sol‐gel transition for various potential applications including targeted drug release, self‐healing, shape memory, and supramolecular adhesion purposes [22–27] . Among these supramolecular hydrogels, amino acid and peptide‐based [1–10] hydrogels attract special attention due to their ease of synthesis, amino acids mutation, purifications and characterizations, structure‐function relationship, building blocks for supramolecular architectonics, biocompatible and biodegradable properties.…”

“…[15][16][17] The stimuli responsive property of hydrogel structure [18][19][20][21] is frequently installed into artificial hydrogel system to carry out sol-gel transition for various potential applications including targeted drug release, self-healing, shape memory, and supramolecular adhesion purposes. [22][23][24][25][26][27] Among these supramolecular hydrogels, amino acid and peptide-based [1][2][3][4][5][6][7][8][9][10] hydrogels attract special attention due to their ease of synthesis, amino acids mutation, purifications and characterizations, structure-function relationship, building blocks for supramolecular architectonics, biocompatible and biodegradable properties. The functional properties of such amino acid and peptide-based supramolecular hydrogels [5,17,18] depend on various external stimuli and there are numerous smart examples of such hydrogels in the literature which are sensitive to temperature, pH, light, enzyme, ultrasound and redox.…”

A biocompatible hydrogel as a template for oxidative decomposition reactions: a chemodosimetric analysis and in vitro imaging of hypochlorite

“…32,42–48 Thus, the development of an effective monitoring device for ClO − is important for quality control and diagnostic purposes. Though recently a few hydrogel systems capable of optical sensing have appeared in the literature, 23,49 reports on ‘reaction-based’ biosensing using hydrogels however remains relatively fewer. 49–56 However, detection strategies based on mild reactions are considered to be more effective than host–guest interactions due to their high specificity.…”

“…Though recently a few hydrogel systems capable of optical sensing have appeared in the literature, 23,49 reports on ‘reaction-based’ biosensing using hydrogels however remains relatively fewer. 49–56 However, detection strategies based on mild reactions are considered to be more effective than host–guest interactions due to their high specificity. Moreover, unlike conventional reaction-based probes (which work on a one-to-one detection strategy), gel-based sensors can amplify the response signal due to long-range intermolecular interactions.…”

Contradiction or Unity? Thermally Stable Fluorescent Probe for In Situ Fast Identification of Self-sort or Co-assembly of Multicomponent Gelators with Sensitive Properties

“…Considering the mechanism of most fluorescent probe molecules with excellent self-assembly properties reported until now, neither aggregation-caused quenching (ACQ) nor aggregation-induced emission (AIE) molecules could show thermally stable properties. For example, in the two-component charge transfer (CT) hydrogel derived from a supramolecular hetero-assembly of a pyrene amino acid conjugate with an acceptor (reported by Santanu Bhattacharya et al), the fluorescence intensity is quenched in the CT hydrogel but can be revived at high temperature due to the heat-mediated dissociation of the CT complex, and the supramolecular polymer based on a pillar[5]­arene tetramer derivative with a tetraphenylethene (TPE) core and four pillarene cavities (reported by Yang et al) causes the decrease of PL intensity since elevated temperature weakens the binding affinities between host–guest systems with the increase of temperature. So, it is necessary to design a new molecule structure by combining the strong self-assembly and special emission mechanism in order to unify the thermal stability in a wide temperature range and the sensitive self-assembly properties.…”