A Twenty-year Retrospective Study of Pediatric Tuberculosis in Two Tertiary Hospitals in Rome

Buonsenso, Danilo; Lancella, Laura; Delogu, Giovanni; Krzysztofiak, Andrzej; Testa, Antonia Carla; Ranno, O; D’Alfonso, Pamela; Valentini, Piero

doi:10.1097/inf.0b013e3182615270

Cited by 38 publications

(52 citation statements)

References 21 publications

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“…In our study the majority of the TB cases (78.6%) were associated with pulmonary involvement supporting the findings of the recent papers from Italy, Denmark and Turkey 11,14,17,18. Nearly 2/3 of the patients had EPTB alone suggesting that EPTB could be underdiagnosed in the absence of pulmonary findings.…”

Section: Discussionsupporting

confidence: 92%

“…Data including demographic characteristics, clinical history, microbiology, imaging studies, medications and outcomes of the patients were collected from medical records. The microbiologically confirmed active TB was defined as the presence of at least one positive clinical specimen for Mycobacterium tuberculosis (Mtb) in culture, or positive AFB smear microscopy, or histological confirmation of caseating granulomas 14. Probable tuberculosis was defined as the presence of suggestive radiologic signs in the absence of bacteriologic confirmation, or radiologic certainty, positive nucleic acid amplification test for Mtb and good clinical response to antitubercular treatment 15…”

Section: Methodsmentioning

confidence: 99%

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Differences Between Pediatric Pulmonary and Extra-Pulmonary Tuberculosis: A Warning Sign for the Future

Devrim

Aktürk

Bayram

et al. 2014

Mediterr J Hematol Infect Dis

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BackgroundTuberculosis (TB) remains a major global health problem. The childhood tuberculosis has some unique features different which makes the diagnosis more complicated. Here we described the epidemiologic, clinical and microbiologic features of children with extra pulmonary and pulmonary TB.MethodsThe data of the patients <14 years with active TB were collected and compared in pulmonary (PTB) and extrapulmonary TB (EXPTB) patients.ResultsA total of 128 cases was included. Forty-two cases occurred in children were < 5 years of age; 41 cases between 6–10 years and 45 cases > 10 years. PTB was present in 75,0% of the cases, and EXPTB was present in 25% of cases. There was no significant difference between the EXPTB and PTB by means of distribution of age groups (p=0,201). The rate of patients free of constitutional symptoms were significantly higher in EXPTB compared to PTB(p=0,000). There was no significant difference between EXPTB and PTB by means of sources detection(p=0,069).ConclusionTB is still a major public health problem. EXPTB has an insidious and silent onset without any constitutional symptoms, and both microbiological confirmation and the source by an adult are not frequently found. Moreover, detection of the adult source is mandatory for controlling the TB disease in children

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Differences Between Pediatric Pulmonary and Extra-Pulmonary Tuberculosis: A Warning Sign for the Future

Devrim

Aktürk

Bayram

et al. 2014

Mediterr J Hematol Infect Dis

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“…Buna karşın, Buonsenso ve ark. 'nın (14) çalışmasında, en sık görülen yakınma ise %51.8 ile ateş olup, bunu %40 ile öksürük izle-miş, boyunda şişlik ise %15.1 oranında saptanmıştır. Çocuklarda tüberküloz hastalığı tanısında ateş, kilo kaybı ve öksürük gibi tipik bulguların tanıda kullanmak yeterli olmayabilir.…”

Section: Sayı (%)unclassified

“…Çocuklarda TB hastalığı tedaviye uyum sağlandığında çoğunlukla iyi prognoz gösterir. Literatürde hastalarda tedavi başarısızlığı %0.4 ve TB'a bağlı mortalite %0-2.2 olarak bildirilmiştir (14,39) . Çalışmamızda, tedavi süresini tamamlayan ve kontrollerine gelen vakaların TB hastalığı başarıyla tedavi edilmişti.…”

Section: Sayı (%)unclassified

Pediatric tuberculosis: A 5-year experience from a Turkish tertiary pediatric hospital

Kamer¹,

Sütçü²,

Acar³

et al. 2017

Cocuk Dergisi

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“…Athelectasia usually seen in middle lobe presented as radiopaque triangular lesions producing lung volume reduction and mediastinal distorsion are frequently seen after mediastinal lymph node enlargement, or pleural effusion, are also common findings especially among patients with an evolved progressive primary infection [20,21]. The absence of pathognomonic radiological findings, and the difficulty to get a positive Mycobacterial culture [22,23] makes it hard to get a definitive diagnosis in children with PTB. Miliary TB, a systemic form of the disease that typically affects children 6 to 11 years old, characterizes by a micronodular pattern consisting of well-defined nodules-in the shape of seeds of millet-uniformly distributed in all lobes, and it is seen usually 6 weeks after primary infection.…”

Section: Radiological Findingsmentioning

confidence: 99%

Clinical, Radiological and Inmunological Features in Children with Pulmonary Tuberculosis: A Review

J¹

2014

J Mycobac Dis

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In the whole world, tuberculosis (TB) continues being an important health problem. It produces a great number of deaths in children, mainly in the wake of the HIV epidemic. In addition, the globalization with the increased of the international travels and the immigration makes that TB control be more difficult. This is a clinical, radiological and immunological review in children TB where we search to contribute the data in the literature. ContextTuberculosis (TB) is one of the most important global health problems. The latest estimates included in the Global tuberculosis report are that there were 8.6 million new TB cases in 2012 and 1.3 million TB deaths worldwide. Of those, 530.000 cases and 74.000 deaths were children [1]. Clinical and radiological findings, such as hemoptisis, cough, caverns or upper-lobe condensations, might be reliable and well established in adults. By contrast, these findings might be more difficult to evaluate in children due to more nonspecific symptoms and heterogeneus radiological findings [2]. ObjectiveThe present work overviews the most important clinical and radiological findings in children diagnosed with tuberculosis infection and disease. We included articles that reported cases with children from 2 months to 13 years. Children were from different backgrounds, and from developed and underdeveloped countries. Data SourcesThe selection of studies for analysis was as follows: all articles published from October 2008 to December 2013, which described clinical and radiological findings of children with TB were selected. These articles were obtained by searching throughout several international databases including Pubmed, Scopus, Highwire Press, Scientific Information Databases, Google Scholar and EBSCO-host.To locate the articles to include in our review, the strategy consisted of an exhaustive search including the following medical subject headings (MeSH) terms: "tuberculosis" or "pulmonary tuberculosis" in combination with "children" or "infant" or "infancy", in combination with "clinical symptoms", "radiological findings", "Mantoux", "tuberculosis diagnosis", "management of tuberculosis" and "tuberculosis treatment". Study SelectionInclusion criteria for systematic review were: 1) Retrospective or prospective cohort studies; 2) Reporting clinical, radiological or Mantoux results in TB patients 3) Studies including data at the national level; and 4) Studies on TB patients meeting either the WHO recommended definitions for "definite cases" or "other than definite cases" or TB patients meeting the possible, probable or confirmed case definition as published by the European Commission in 2008.Opinion articles, editorials, comments, case studies and/or drug efficacy tested in vitro or through clinical trials were excluded from the systematic review. Furthermore, those articles not published in English or Spanish language were excluded from the review. Literature searching was performed until 1 st December 2013. Using the search terms previously described above, fifty-three st...

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A Twenty-year Retrospective Study of Pediatric Tuberculosis in Two Tertiary Hospitals in Rome

Cited by 38 publications

References 21 publications

Differences Between Pediatric Pulmonary and Extra-Pulmonary Tuberculosis: A Warning Sign for the Future

Differences Between Pediatric Pulmonary and Extra-Pulmonary Tuberculosis: A Warning Sign for the Future

Pediatric tuberculosis: A 5-year experience from a Turkish tertiary pediatric hospital

Clinical, Radiological and Inmunological Features in Children with Pulmonary Tuberculosis: A Review

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