A turn-on fluorescent probe with high selectivity for Hg<sup>2+</sup> and its applications in living cells

Li, Bin; Tian, Fang; Hua, Yupeng

doi:10.1039/d2ra02185d

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…Competition experiment is carried out for the L-Hg 2+ complex, and its unaffected by other metal ions. Fluorescence titration shows when the concentration of Hg is increased to 1.3x10 -5 , the fluorescence emission is increased by 55 fold [13]. A 1:1 stoichiometry is determined for the formation of the L-Hg 2+ complex.…”

Section: Hg (Ii)mentioning

confidence: 93%

Review of the detection of metal ions using fluorescent probes

2023

TNS

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Metal ions, essential for numerous physiological functions of the human body require accurate monitoring in order to gain precise knowledge of the health status of people. As fluorescent probes advances, the level of metal ions can be measured with high selectivity and sensitivity. Allowing the homeostasis of numerous metal ions to be maintained easily. Fluorescent probes are a hot area of research, providing a prospective tool for the detection of metal ions and to provide critical statistics in maintaining the homeostasis of the human body. This article introduces several fluorescent probes on the detection of both essential and toxic metal ions. It gives a review about the recent development in the detection of metal ions using fluorescent probes. This article explains the mechanism of recognition of each fluorescent probe and summarizes the results obtained from experiments. Outlining the advantages and shortcomings of each fluorescent probe. It includes novel fluorescent probes based on uncommon mechanisms.

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Section: Hg (Ii)mentioning

confidence: 93%

Review of the detection of metal ions using fluorescent probes

2023

TNS

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“…由于通过螺环开环并与 Hg 2 ＋配位来检测 Hg 2 ＋是最常见的作用机制 [113] , 故为了增强探针与 Hg 2 ＋的配位能力和探针的灵敏度 [114] , 常对罗丹明结构进行修饰, 以引入可与 Hg 2 ＋配位的含 N、O、S 等杂原子结构 [115] . 例图式 5 探针 17 的合成及其作用机理 Scheme 5 Synthesis of fluorescent probe 17 and its function mechanism 如, 最近田福利课题组 [116] 通过以罗丹明 B 酰肼和 3-甲基-2-噻吩甲醛为原料, 通过席夫碱反应, 合成了新型的罗丹明探针 18 (Eq. 12).…”

Section: 开环反应类断键型小分子探针unclassified

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

Li,

Chen,

Chen

et al. 2023

Chinese Journal of Organic Chemistry

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Mercury has strong biological toxicity and poses great harm to human health and the environment. Fluorescent probes have been widely applied in the detection of mercury ion in recent years, due to these probes with high sensitivity, high selectivity, and real-time monitoring. Owing to the advantages of small molecules such as structural diversity, good repeatability, easy modification, and clear sensing mechanisms, many organic small molecular fluorescence probes for detecting mercury ion have also been developed. According to the different reaction mechanisms between probes and mercury ion, these organic small molecular fluorescence probes can be classified into two categories based on coordination type reactions and bond breaking type reactions. The research progress of organic small molecular fluorescence probes used to detect mercury ion in the past five years is summarized in detail. This provides a reference for their further development in the future, especially for the new turn-on type reactive organic small molecular fluorescence probes for detecting mercury ion by utilizing the characteristic reactions. Keywords mercury ion detection; fluorescent probes; organic small molecules; reaction mechanism; molecular design and synthesis 汞是一种剧毒的不可降解的金属污染物 [1] , 一旦进入生物体, 就会在生物体内累积, 影响蛋白质和酶的正常功能, 进而导致各种急性中毒事件 [2] . 因此, 建立一种灵敏、选择性检测汞离子的有效分析方法, 对汞离子的监测、临床诊断及治疗具有重要意义 [3] . 与用来检测汞离子的传统分析方法, 如伏安法、原子吸收光谱法、 X 射线吸收光谱法、分光光度法等相比, 荧光探针具有高选择性、响应速度快和可实时监测等优点 [4] . 这使得汞离子荧光探针引起了研究人员极大的关注, 并得到了高速发展 [5][6][7] .

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A Ratiometric Green Fluorescent Carbazole‐Bis(hydrazinobenzothiazole) Probe for the Selective Detection of Toxic Hg²⁺ Ions in Real Water Samples

Leslee,

Karuppannan

2024

ChemPlusChem

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A dyad Carbazolyl‐bis(hydrazinobenzothiazole) was designed to form a symmetrical structure that containing two‐arm active binding sites facilitates coordination with Hg2+ ion. This sensor has imparted a colorimetric and fluorometric changes in presence of Hg2+ ions. The ligand showed a selective blue shift in presence of Hg2+even in co‐existence with heavy metal ions with luminescence change from colorless to blue and colorless to green under day light. Enhanced Intramolecular charge transfer process is responsible for fluorescence transformation when ligand interacts with Hg2+ ion. The emission spectra showed a ratiometric response to increasing addition of Hg2+ ions. The sensor is capable of detecting above the lower concentration of 6.8025 × 10‐8 M. The fluorescence efficiency of CBT‐2 with Hg2+ ion is quite stable under different co‐metal ions and wide range of pH 6 to 9. The sensor CBT‐2 forms a 1:1 stoichiometric complex with Hg2+ ions and the binding nature is confirmed from the 1H‐NMR, FTIR, and mass spectroscopic studies. The sensor CBT‐2 and its Hg2+ complex possess good binding nature to protein in Bovine Serum Albumin which could be good in biological applications. Additionally, wedevelop a practical application in real water sample analysis and electrochemical detection viaoxidation potential discrimination.

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A turn-on fluorescent probe with high selectivity for Hg²⁺ and its applications in living cells

Abstract: A novel colorimetric fluorescent probe with low detection limits has been designed and synthesized, which shows an unique response for Hg2+ in living cells.

Cited by 6 publications

References 27 publications

Review of the detection of metal ions using fluorescent probes

Review of the detection of metal ions using fluorescent probes

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

A Ratiometric Green Fluorescent Carbazole‐Bis(hydrazinobenzothiazole) Probe for the Selective Detection of Toxic Hg²⁺ Ions in Real Water Samples

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A turn-on fluorescent probe with high selectivity for Hg2+ and its applications in living cells

Abstract: A novel colorimetric fluorescent probe with low detection limits has been designed and synthesized, which shows an unique response for Hg2+ in living cells.

Cited by 6 publications

References 27 publications

Review of the detection of metal ions using fluorescent probes

Review of the detection of metal ions using fluorescent probes

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

A Ratiometric Green Fluorescent Carbazole‐Bis(hydrazinobenzothiazole) Probe for the Selective Detection of Toxic Hg2+ Ions in Real Water Samples

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Product

Resources

About

A turn-on fluorescent probe with high selectivity for Hg²⁺ and its applications in living cells

A Ratiometric Green Fluorescent Carbazole‐Bis(hydrazinobenzothiazole) Probe for the Selective Detection of Toxic Hg²⁺ Ions in Real Water Samples