“…SO 2 can dissolve easily in water to form its derivatives bisulfite (HSO 3 − ) and sulfite (SO 3 2− ), so the physiological functions of SO 2 can be attributed to its derivatives (HSO 3 − /SO 3 2− ). However, a high level of endogenous SO 2 , generated by the oxidation of H 2 S and thiol-containing amino acids in mitochondria, may bring about neurological disorders, cancers and other diseases [ 5 , 6 , 7 , 8 ]. Hence, it is greatly important to establish sensitive and rapid methods for SO 2 detection to further gain insight into its functions in biological systems, especially in mitochondria.…”