A Turkish Gynecologic Oncology Group study of fertility‐sparing treatment for early‐stage endometrial cancer

Dursun, Polat; Erkanli, Serkan; Güzel, Ahmet Barış; Gültekin, Murat; Tarhan, Nefise Çağla; Altundağ, Özden; Demirkıran, Fuat; Beşe, Tugan; Yıldırım, Yusuf; Bozdağ, Gürkan; Yaralı́, Hakan; Şimşek, Tayyup; Özçelik, Bülent; Ortaç, Fırat; Taşkın, Salih; Güvenal, Tevfik; Özgül, Nejat; Haberal, Alı; Dede, Murat; Yenen, Müfit Cemal; Altintaş, Aytekin; Arvas, Macit; Ayhan, Ali

doi:10.1016/j.ijgo.2012.06.010

Cited by 28 publications

(15 citation statements)

References 23 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were 33 studies that included only endometrial cancer and three studies that included only atypical hyperplasia . There were 13 studies that included patients with grade 2 endometrial cancer and three studies that included patients with grade 3 endometrial cancer . One study included patients with myometrial invasion …”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta‐analysis of prognostic factors for remission in fertility‐sparing management of endometrial atypical hyperplasia and adenocarcinoma

Guillon

Popescu

Phelippeau

et al. 2019

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Background: Endometrial cancer and atypical hyperplasia are rare in young women but create a dilemma between desire for pregnancy and oncologic outcomes.Objective: To identify remission rates and associated prognostic factors in patients undergoing fertility-sparing management for endometrial cancer and atypical hyperplasia. Search strategy: MEDLINE was searched for studies published between January 1, 1950 and July 31, 2017 using various search terms. Selection criteria: Studies evaluating fertility-sparing management in patients aged between 19 and 44 years with atypical hyperplasia or stage I endometrial cancer. Data collection and analysis: Use of PRISMA guidelines to conduct a meta-analysis of the proportion of patients in remission and meta-regression analysis to test the effect of possible prognostic factors for remission.Main results: A total of 3673 studies were screened; 65 studies including 1604 patients met the inclusion criteria. The remission rate was 0.75 (95% CI, 0.73-0.77).Operative hysteroscopy for endometrial sampling was associated with higher remission rates (OR 2.31; 95% CI, 1.10-4.84; P=0.03). Studies with higher ratios of infertile women were associated with higher remission rates (OR 4.21; 95% CI, 1.44-12.33; P<0.01). Conclusion:Operative hysteroscopy is the preferred endometrial sampling method for patients with atypical hyperplasia or endometrial cancer undergoing fertilitysparing management.

show abstract

Section: Resultsmentioning

confidence: 99%

A systematic review and meta‐analysis of prognostic factors for remission in fertility‐sparing management of endometrial atypical hyperplasia and adenocarcinoma

Guillon

Popescu

Phelippeau

et al. 2019

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…In a multicenter study of 43 patients was conducted five months conservative treatment. In the follow-up period of 49 months in 2 cases subsequently relapsed, and 31 pregnant women from 3 to 18 months after treatment [23]. and nonhereditary genetic diseases [15].…”

Section: Discussionmentioning

confidence: 99%

Endometrial Carcinoma in a 20 Years Old or Less Female: A Rare Presentation of Four Cases

Chakalova¹

2013

J Clin Case Rep

View full text Add to dashboard Cite

“…So far, there have been an increasing number of successful deliveries after conservative treatment for EC/ACEH [2][3][4]. We suppose that many patients undergo infertility treatment including assisted reproductive technology (ART), because we speculate most of the patients have ovulation disorders, which could contribute to the occurrence of the disease.…”

Section: Introductionmentioning

confidence: 99%

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Fujimoto

Ichinose

Harada

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To elucidate the problems in infertility treatment for women after conservative therapy for endometrial cancer (EC) or atypical complex endometrial hyperplasia (ACEH). Methods The clinical outcomes of 21 patients who underwent assisted reproductive technology after conservative therapy (group A) and 42 control women (group B) were retrospectively analyzed. Results There was no significant difference in the number of retrieved oocytes, fertilization rate or the number of transferred embryos between the two groups. Women in group A had a significantly thinner endometrium and a reduced implantation rate compared to those for women in group B. There was no significant difference in the cumulative clinical pregnancy and delivery rates between group A and B. The patients in group A required significantly more embryos for achieving a live-birth. Conclusions Our results indicate that a thin endometrium after repeated curettage may have a negative effect on endometrial receptivity of patients after conservative treatment for EC/ACEH. Clinicians should reconsider their present protocols and make efforts to minimize the damage to normal endometrium.

show abstract

A Turkish Gynecologic Oncology Group study of fertility‐sparing treatment for early‐stage endometrial cancer

Abstract: Conservative management of early-stage EC in women of reproductive age using oral progestins was effective and did not compromise oncological outcome. Pregnancy in the study patients was achieved spontaneously and artificially.

Cited by 28 publications

References 23 publications

A systematic review and meta‐analysis of prognostic factors for remission in fertility‐sparing management of endometrial atypical hyperplasia and adenocarcinoma

A systematic review and meta‐analysis of prognostic factors for remission in fertility‐sparing management of endometrial atypical hyperplasia and adenocarcinoma

Endometrial Carcinoma in a 20 Years Old or Less Female: A Rare Presentation of Four Cases

The outcome of infertility treatment in patients undergoing assisted reproductive technology after conservative therapy for endometrial cancer

Contact Info

Product

Resources

About