A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis

Qi, Lin; Cao, Jun; Shao, Kun; Tong, Fan; Yang, Zhipeng; Lei, Ting; Wang, Yazhen; Hu, Chuan; Umeshappa, Channakeshava Sokke; Gao, Huile; Peppas, Nicholas A.

doi:10.1126/sciadv.abb3116

Cited by 107 publications

(85 citation statements)

References 43 publications

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“… 18 , 19 Additionally, ICG is also a photosensitizer with excellent photothermal conversion efficiency when exposed to single wavelength NIR light. 14 , 20 These attractive features indicate that ICG could be a promising dye for tumor imaging and PTT. 11 , 21 So far, ICG has been used for the determination of liver function and liver blood flow, 22 cardiac output, 23 and ophthalmic angiography.…”

Section: Introductionmentioning

confidence: 99%

A Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer

Shao

Liang

Ding

et al. 2021

IJN

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Background Surgery is considered to be a potentially curative approach for gastric cancer. However, most cases are diagnosed at a very advanced stage for the lack of typical symptoms in the initial stage, which makes it difficult to completely surgical resect of tumors. Early diagnosis and precise personalized intervention are urgent issues to be solved for improving the prognosis of gastric cancer. Herein, we developed an RGD-modified ROS-responsive multifunctional nanosystem for near-infrared (NIR) imaging and photothermal therapy (PTT) against gastric cancer. Methods Firstly, the amphiphilic polymer was synthesized by bromination reaction and nucleophilic substitution reaction of carboxymethyl chitosan (CMCh) and 4-hydroxymethyl-pinacol phenylborate (BAPE). Then, it was used to encapsulate indocyanine green (ICG) and modified with RGD to form a smart multifunctional nanoparticle targeted to gastric cancer (CMCh-BAPE-RGD@ICG). The characteristics were determined, and the targeting capacity and biosafety were evaluated both in vitro and in vivo. Furthermore, CMCh-BAPE-RGD@ICG mediated photothermal therapy (PTT) effect was studied using gastric cancer cells (SGC7901) and SGC7901 tumor model. Results The nanoparticle exhibited suitable size (≈ 120 nm), improved aqueous stability, ROS-responsive drug release, excellent photothermal conversion efficiency, enhanced cellular uptake, and targeting capacity to tumors. Remarkably, in vivo studies suggested that CMCh-BAPE-RGD@ICG could accurately illustrate the location and margin of the SGC7901 tumor through NIR imaging in comparison with non-targeted nanoparticles. Moreover, the antitumor activity of CMCh-BAPE-RGD@ICG-mediated PTT could effectively suppress tumor growth by inducing necrosis and apoptosis in cancer cells. Additionally, CMCh-BAPE-RGD@ICG demonstrated excellent biosafety both in vitro and in vivo. Conclusion Overall, our study provides a biocompatible theranostic nanoparticle with enhanced tumor-targeting ability and accumulation to realize NIR image-guided PTT in gastric cancer.

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Section: Introductionmentioning

confidence: 99%

A Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer

Shao

Liang

Ding

et al. 2021

IJN

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“…Our group designed a dendrimer-loaded α -cyclodextrin (CD)-based hydrogel to meet the requirement of LDIMP cascade ( Fig. 7 ) 107 . In the system, PAMAM with small size was conjugated with CpG as adjuvant and reductive-cleavable 4-aminophenyl- α - d -mannopyranoside (MAN) to improve lymph targeting and DC internalization (CpG-P-ss-M).…”

Section: Stimulating Antitumor Immunity Responsementioning

confidence: 99%

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

Zhang

Wang

et al. 2020

Acta Pharmaceutica Sinica B

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131

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As one of the most serious threats to human being, cancer is hard to be treated when metastasis happens. What's worse, there are few identified targets of metastasis for drug development. Therefore, it is important to develop strategies to prevent metastasis or treat existed metastasis. This review focuses on the procedure of metastasis, and first summarizes the targeting delivery strategies, including primary tumor targeting drug delivery, tumor metastasis targeting drug delivery and hijacking circulation cells. Then, as a promising treatment, the application of immunotherapy in tumor metastasis treatment is introduced, and strategies that stimulating immune response are reviewed, including chemotherapy, photothermal therapy, photodynamic therapy, ferroptosis, sonodynamic therapy, and nanovaccines. Finally, the challenges and perspective about nanoparticle-enabled tumor metastasis treatment are discussed.

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“…There are diverse applications for thermosensitive hydrogels, including bacterial infected wound healing ( Yan et al, 2019 ), tumor treatment ( Jia et al, 2020 ; Qin et al, 2020 ; Yuan et al, 2020 ), and tissue regeneration ( Zhao C. et al, 2020 ). Recently, Almoshari et al (2020) synthesized an intelligent hydrogel by blending pyrophosphorylated Pluronic F127 (F127-PPi) with regular F127 to contain the hydrophobic glycogen synthase kinase 3 beta inhibitor, which could provide functions of inflammation modulating and osteoanagenesis.…”

Section: Smart Hydrogel In Biomedical Applicationmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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A tumor-to-lymph procedure navigated versatile gel system for combinatorial therapy against tumor recurrence and metastasis

Cited by 107 publications

References 43 publications

A Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer

A Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

Rational Design of Smart Hydrogels for Biomedical Applications

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