A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

Fu, Hong‐Guang; Chen, Yong; Yu, Qilin; Liu, Yu

doi:10.1039/c8cc09964b

Cited by 51 publications

(38 citation statements)

References 36 publications

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“…Liu and coworkers synthesised a poly-phenanthroline Ru II photosensitizer with 3 pendant cyclodextrin groups which strongly associate with adamantane-functionalized transferrin molecules via non-covalent binding of the adamantane group to the cyclodextrin cavity. [18] Notably, the resulting supramolecular assembly exhibited selective accumulation in A549 lung cancer cells through transferrin receptor-mediated endocytosis, displaying promising PDT efficiency. Interestingly, glutathione was found to have a protective role in A549 cells during irradiation treatment with this supramolecular system.…”

Section: Protein-assisted Delivery Of Metal-based Photosensitizersmentioning

confidence: 99%

New Designs for Phototherapeutic Transition Metal Complexes

et al. 2019

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In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light‐activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side‐effects. The photophysical and photochemical properties of transition metal complexes can be controlled by the appropriate choice of the metal, its oxidation state, the number and types of ligands, and the coordination geometry.

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Section: Protein-assisted Delivery Of Metal-based Photosensitizersmentioning

confidence: 99%

New Designs for Phototherapeutic Transition Metal Complexes

et al. 2019

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“…Our previous research showed that Ru‐HOP‐CD emits ultrahigh near‐infrared fluorescence with excellent fatigue resistance, making it an ideal photosensitizer. [ 17 ] Here, we found that owing to the presence of the dithienylethene unit, complex 1 could undergo reversible photocyclization. Notably, the emission of Ru‐HOP‐CD overlapped poorly with the absorption of ring‐opened 1 (OF‐ 1 ) but showed good overlap with the absorption of ring‐closed 1 (CF‐ 1 ), implying the possibility of photoswitchable fluorescence resonance energy transfer (FRET) from Ru‐HOP‐CD to CF ‐1 .…”

Section: Methodsmentioning

confidence: 92%

“…Ru‐HOP‐CD was synthesized in satisfactory yield by means of our reported method and was fully characterized. [ 17 ] OF ‐1 was synthesized as shown in Scheme S1, Supporting Information: treatment of 3 with 1‐(adamantan‐1‐yl)‐2‐bromoethanone in acetone containing K 2 CO 3 produced OF‐ 1 (81% yield), which was fully characterized by 1 H and 13 C NMR spectroscopy and high‐resolution mass spectrometry. OF‐ 2 nanoparticles were then synthesized by adding an aqueous solution containing Ru‐HOP‐CD and cetrimonium bromide to a glass vial coated with a thin‐film polymer prepared from OF ‐1 and Pluronic F‐127.…”

Section: Methodsmentioning

confidence: 99%

Quaternary Supramolecular Nanoparticles as a Photoerasable Luminescent Ink and Photocontrolled Cell‐Imaging Agent

Chen

Dai

et al. 2020

Advanced Optical Materials

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Photoswitchable luminescent supramolecular assemblies based on cyclodextrins have attracted considerable attention owing to their potential applications as smart materials, but most of the assemblies reported to date emit green or blue light with low contrast and high interference. In this study, novel photoluminescent red‐luminescent quaternary supramolecular nanoparticles (2) are constructed from a dithienylethene derivative (1), a β‐cyclodextrin‐functionalized ruthenium complex (Ru‐HOP‐CD), Pluronic F‐127, and cetrimonium bromide. Compared with the binary assembly 1@Ru‐HOP‐CD, the quaternary nanoparticles exhibit high fluorescence resonance energy transfer efficiency, with Ru‐HOP‐CD acting as the donor and 1 as the acceptor. Owing to the reversible photoswitched interconversion of the two forms of the dithienylethene component, the fluorescence of the nanoparticles could be switched on/off by irradiation with UV or visible light, both in solution and in the solid state. As a result, the nanoparticles could be used as a photoerasable red‐luminescent ink and as a photocontrolled cell‐imaging agent. These functional nanoparticles can be expected to be useful in the fields of information security and biology.

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“…Significantly, the resultant Ru/polysaccharide/protein complex exhibited not only specific targeting properties toward tumor cells but also high PDT ability under visible light irradiation. Furthermore, the assembly showed selective killing toward tumor cells combined with negligible toxicity toward normal cells [19].…”

Section: Macrocycle-based Supermolecules As Antitumor Agentsmentioning

confidence: 99%