A truly hybrid interventional MR/X‐ray system: Feasibility demonstration

Fahrig, Rebecca; Butts, Kim; Rowlands, J. A.; Saunders, Rowland; Stanton, John F.; Stevens, Grant M.; Daniel, Bruce L.; Wen, Zhifei; Ergun, David L.; Pelc, Norbert J.

doi:10.1002/1522-2586(200102)13:2<294::aid-jmri1042>3.3.co;2-o

Cited by 17 publications

(20 citation statements)

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“…Multimodality particles would allow shunt and reflux detection in both modalities, which would be especially interesting in multimodal treatment units. 9 A multimodal environment would allow a combined treatment procedure, with catheter placement under fluoroscopy and embolization monitoring under MRI guidance.…”

Section: Discussionmentioning

confidence: 99%

“…8 Conventional embolization therapy requires performance in an x-ray-based digital subtraction angiography (DSA) unit, to achieve catheter guidance and monitoring of the embolization procedure. 9 State-of-the-art angiography systems provide an integrated computed tomography (CT) scanning mode for intraprocedural imaging. 10 There is an increasing interest to introduce magnetic resonance imaging (MRI) in the Interventional Radiology setup, as it avoids radiation exposure for the patient, which is a major concern in the treatment of benign lesions, especially in young female patients.…”

mentioning

confidence: 99%

“…[11][12][13] Unfortunately, MRI is currently limited as a standalone system for Interventional Radiology and therefore multimodal setups as well as hybrid systems have been introduced. 1,9,14,15 Many different embolization materials have been described. 1 For tumor embolization, particles consisting of polyvinyl alcohol 16 or microspheres loaded with chemotherapeutic agents 17 are considered state of the art in clinical treatment concepts.…”

mentioning

confidence: 99%

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First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

Bartling¹,

Budjan²,

Aviv³

et al. 2011

Investigative Radiology

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Multimodal-visible embolization particles have been developed, characterized, and tested in vivo in an animal model. Their implementation in clinical radiology may provide optimization of embolization procedures with regard to prevention of particle misplacement and direct intraprocedural visualization, at the same time improving follow-up examinations by utilizing the complementary characteristics of CT and MRI. Radiation dose savings can also be considered. All these advantages could contribute to future refinements and improvements in embolization therapy. Additionally, new approaches in embolization research may open up.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

Bartling¹,

Budjan²,

Aviv³

et al. 2011

Investigative Radiology

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“…Patients can be rapidly transferred between the two imaging modalities on a common floating table. Although this is the commonest configuration, another configuration has been reported in which the x-ray system is integrated into the MR system [8]. XMR systems are designed to provide a migration path to MR guided intervention.…”

Section: Procedures Guidancementioning

confidence: 99%

XMR guided cardiac electrophysiology study and radio frequency ablation

et al. 2004

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Introduction: XMR systems are a new type of interventional facility in which patients can be rapidly transferred between x-ray and MR systems on a floating table. We have previously developed a technique to register MR and x-ray images obtained from such systems. We are carrying out a programme of XMR guided cardiac electrophysiology study (EPS) and radio frequency ablation (RFA). Aim: The aim of our work was to apply our registration technology to XMR guided EPS/RFA in order to integrate anatomical, electrophysiological and motion information. This would assist in guidance and allow us to validate and refine electromechanical models. Method: Registration of the imaging modalities was achieved by a combination of system calibration and real-time optical tracking. Patients were initially imaged using MR imaging. An SSFP volume scan of the heart was acquired for anatomical information, followed by tagged scans for motion information. The patients were then transferred to the x-ray system. Tracked biplane x-ray images were acquired while electrical measurements were made from catheters placed in the heart. The relationship between the MR and x-ray images was determined. The MR volume scan of the heart was segmented and the tagged scans were analysed using a nonrigid registration algorithm to compute motion. The position of catheters was reconstructed within the MR cardiac anatomy. The anatomical, electrophysiological, and motion information were displayed in the same coordinate system. Simulations of electrical depolarisation and contraction were performed using electromechanical models of the myocardium. Results: We present results for 2 initial cases. For patient 1, a contact mapping system was used for the EPS and for patient 2, a noncontact mapping system was used. Conclusions: Our XMR registration technique allows the integration of anatomical, electrophysiological, and motion information for patients undergoing EPS/RFA. This integrated approach has assisted in interventional guidance and has been used to validate electromechanical models of the myocardium.

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“…Generally, the frame rate of intraoperative real-time MRI is less than 10 fps for 2D imaging, and at this frame rate these systems cannot capture motion of the target straying off the imaging slice. Integration of other imaging modalities, such as those using ultrasound (12,13) and x-ray radiation (14,15), with MRI has been discussed in the research community. These modalities have sufficiently high frame rates to track a moving target organ, and clinicians can choose a suitable imaging modality at any moment during therapy.…”

mentioning

confidence: 99%

Adaptive 4D MR imaging using navigator‐based respiratory signal for MRI‐guided therapy

Tokuda

Morikawa

Haque

et al. 2008

Magnetic Resonance in Med

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For real-time 3D visualization of respiratory organ motion for MRI-guided therapy, a new adaptive 4D MR imaging method based on navigator echo and multiple gating windows was developed. This method was designed to acquire a time series of volumetric 3D images of a cyclically moving organ, enabling therapy to be guided by synchronizing the 4D image with the actual organ motion in real time. The proposed method was implemented in an open-configuration 0.5T clinical MR scanner. To evaluate the feasibility and determine optimal imaging conditions, studies were conducted with a phantom, volunteers, and a patient. In the phantom study the root mean square (RMS) position error in the 4D image of the cyclically moving phantom was 1.9 mm and the imaging time was Ϸ10 min when the 4D image had six frames. In the patient study, 4D images were successfully acquired under clinical conditions and a liver tumor was discriminated in the series of frames. The image quality was affected by the relations among the encoding direction, the slice orientation, and the direction of motion of the target organ. In conclusion, this study has shown that the proposed method is feasible and capable of providing a real-time dynamic 3D atlas for surgical navigation with sufficient accuracy and image quality.

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A truly hybrid interventional MR/X‐ray system: Feasibility demonstration

Cited by 17 publications

References 0 publications

First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

XMR guided cardiac electrophysiology study and radio frequency ablation

Adaptive 4D MR imaging using navigator‐based respiratory signal for MRI‐guided therapy

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