A triterpene from Rubus pinfaensis

Durham, David G.; Liu, Xiaojun; Richards, R. M. E.

doi:10.1016/s0031-9422(00)89744-7

Cited by 39 publications

(28 citation statements)

References 9 publications

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“…Compounds 17 and 24 were obtained from the Rosaceae family for the first time. The known compounds were identified as euscaphic acid (9) (Wang et al, 2003), 2-oxo-pomolic acid (10) (Wang et al, 2003), 18,19-seco,2a,3a-dihydroxyl-19-oxours-11,13(18)-dien-28-oic acid (11) (Huang et al, 2005), ursolic acid (12) (Wang et al, 2003), 1b-hydroxyeuscaphic acid (13) (Wang and Yuan, 2009), pinfaensic acid (14) (Durham et al, 1994), tormentic acid (15) (Wang et al, 2003), uvaol (16) (He et al, 2012), 3b-hydroxytaraxastan-28,20b-olide (17) (Errington and Jefferies, 1988), fupenzic acid (18) (Wang et al, 2003), pomolic acid (19) (Wang et al, 2003), annurcoic acid (20) (D'Abrosca et al, 2006), 2a,3a,19a,23-tetrahydroxyursolic acid (21) (Brieskorn and Riedel, 1977), swinhoeic acid (22) (Zhao et al, 2001), 1b-hydroxy-2-oxopomolic acid (23) (Ahn et al, 2012), 2a,3b-dihydroxyolean-11,13(18)-dien-19b,28-olide (24) (Lin et al, 2013), and 2a,3a-dihydroxyolean-12-en-28-oic acid (25) (Niu et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

et al. 2015

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“…The inhalation of phytoncides is known as forest bathing and aromatherapy. Chemical and pharmacological studies have shown that some species produce active principles that exert anti-gastropathic, anti-inflammatory, antioxidant activity [13][14][15] . It has been reported that physiological effects of phytoncides contribute to the improvement of various disorders including accelerated aging, allergies, multiple sclerosis, and Parkinson disease 16,17) .…”

Section: Introductionmentioning

confidence: 99%

Protecting Effect of Phytoncide Solution, on Normal Human Dermal Fibroblasts against Reactive Oxygen Species

et al. 2009

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“…[2][3][4] Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity. [5][6][7] Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives.…”

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Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

Kanegusuku

Sbors

Bastos

et al. 2007

Biological & Pharmaceutical Bulletin

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Rosaceae consists of a large family of plants, represented by fruits such as plums, cherries, damson plums, quinces, strawberries, pears and peaches.1) The plants to the genus Rubus, have been traditionally used to treat different diseases, particularly diabetes.2-4) Chemical and pharmacological studies have shown that some species produce active principles that exert antigastropathic, antiinflammatory, antioxidant activity.5-7) Besides these activities, it has been reported that extracts of some species of this genus are potential antimicrobial and analgesic sources. [8][9][10] Phytochemical studies carried out with these plants indicate the presence of steroids, triterpene and ellagic acid derivatives. 8,9,11) Recently, we have shown that another species, R. imperialis, presents hypoglycaemic, cytotoxic and antinociceptive actions. 9,[11][12][13] The main isolated active compound, named niga-ichigoside F1, showed marked antinociception and its mechanism of action appears to be related to the dopaminergic, cholinergic, glutamatergic, and tachykininergic and oxinitrergic systems. 14)Rubus rosaefolius, popularly known as "amora-do-mato" or "amora-vermelha" in Brazil, is a shrub measuring between 4 and 5 m, and is well distributed in the South of Brazil. 1,15) The current study extends our previous work on the biological properties of the Rubus species, and describes its phytochemical analysis and in vivo antinociceptive activity against two pain models in mice (writhing and formalin tests) of the extract, fractions and a pure compound isolated from the aerial parts of R. rosaefolius. Phytochemical Analysis Air-dried material from R. rosaefolius (700 g) was cut into small pieces and macerated with methanol at room temperature for 7 d. After filtration, the solvent was removed by rotatory evaporation under reduced pressure, yielding the respective methanolic extract (ME). Parallel to this, a hydroalcoholic extract (HE) was prepared through maceration of 100 g of plant with an ethanol-water (50 : 50) mixture and stored for use in the pharmacological test. The methanolic extract (35 g), were then suspended in a MeOH : water mixture (9 : 1) and successively partitioned with n-hexane, dichlomethane, ethyl acetate and n-butanol, to provide the respective fractions. The hexane and dichloromethane fractions (7.4, 4.2 g) were chromatographed on silica gel column eluted with a hexane : acetone mixture with increasing polarity. Similar fractions, which showed a positive reaction with anisaldehyde sulfuric reagents, were combined and rechromatographed as in the The Rubus species has been used in folk medicine to treat several ailments, including infectious and dolorous diseases. In this work we evaluate the phytochemical and analgesic activity of hydroalcoholic extract (HE), some fractions (hexane, dichloromethane, ethyl acetate and butanolic), as well as a pure compound denoted as 28-methoxytormentic acid (1) obtained from aerial parts of R. rosaefolius. The compounds were isolated and identified by chromatographic and spect...

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A triterpene from Rubus pinfaensis

Cited by 39 publications

References 9 publications

Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

Ursane-type nortriterpenes with a five-membered A-ring from Rubus innominatus

Protecting Effect of Phytoncide Solution, on Normal Human Dermal Fibroblasts against Reactive Oxygen Species

Phytochemical and Analgesic Activity of Extract, Fractions and a 19-Hydroxyursane-Type Triterpenoid Obtained from Rubus rosaefolius (Rosaceae)

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