This chapter is based on the premise that the utopian goal of education is to unify various strands of knowledge as opposed to dividing it. Ideally education should nurture talent in the classroom and create wellrounded individuals akin to the great thinkers of the Renaissance. That is, individuals who are able to pursue multiple fields of research and appreciate both the aesthetic and the structural/scientific connections between mathematics, arts, and the sciences. We will explore an under addressed aspect of giftedness, namely the role of interdisciplinary activities and problems to foster talent in and across the disciplines of mathematics, science and humanities, increasingly important for emerging professions in the twenty-first century. Examples from the history of mathematics, science and arts will be used to argue for the value of such activities to foster polymathic traits in gifted individuals, particularly the questioning of paradigms. Recent findings from classroom studies will be used to illustrate the value of such an approach to gifted education.