A tribute to D'Arcy Wentworth Thompson: Elucidation of a developmental principle

Abstract

We show the vertebrate anterior -posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox-Hox interactions. 4/ 'Decision points' involving signalling pathways separate axial domains.

Abnormal Elongations of HOX Gene Clusters May Cause Cancer

“…This “current dogma” on collinearity was recently challenged by Durston and Zhu. These authors emphasize the importance of multiscalar phenomena as combined with a spirit of “going back to basics” (Durston and Zhu, 2017 ). This is exactly what inspired the biophysical model several years ago (Papageorgiou, 2001 ).…”

On “Growth and Form” and ASAPbio reform (Editorial)

“…Scientific work and creation by Stephen Jay Gould, Conrad Waddington, John Maynard Smith, Alan Turing, Paul Jackson Pollock, Eduardo Paolozzi, and others may serve as examples. This seems to be especially true regarding the most striking Thompson's theory of transformed coordinates (Briscoe and Kicheva, 2017;Durston and Zhu, 2017;De Robertis, Moriyama, and Colozza, 2017). According to the theory, different biological forms can be explained through Cartesian coordinate transformations of another form.…”