A tribo-mechanical analysis of PVA-based building-blocks for implementation in a 2-layered skin model

Hurtado, Marina Morales; Vries, Erik G. de; Zeng, Xiangqiong; Heide, Emile van der

doi:10.1016/j.jmbbm.2016.05.001

Cited by 9 publications

(2 citation statements)

References 67 publications

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“…Hydrogels that mimic the human skin could promote accelerated healing. A two-layered PVA hydrogel has similar mechanical properties to skin [43]; a three-layered sodium alginate–chitosan–Ca-polyglycolic acid hydrogel for Ca 2+ release on the wound site showed 1000% water uptake and stimulated re-epithelization [44]. Laminated PVA hydrogels, in which each layer is submitted to different numbers of freeze–thawing cycles, is a potential drug delivery device able to sustain a constant delivery rate.…”

Section: Introductionmentioning

confidence: 99%

Physically Cross-Linked Gels of PVA with Natural Polymers as Matrices for Manuka Honey Release in Wound-Care Applications

Santos

Moreira²,

Carvalho

et al. 2019

Materials

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Manuka honey is a well-known natural material from New Zealand, considered to have properties beneficial for burn treatment. Gels created from polyvinyl alcohol (PVA) blended with natural polymers are potential burn-care dressings, combining biocompatibility with high fluid uptake. Controlled release of manuka honey from such materials is a possible strategy for improving burn healing. This work aimed to produce polyvinyl alcohol (PVA), PVA–sodium carboxymethylcellulose (PVA-CMC), PVA–gelatin (PVA-G), and PVA–starch (PVA-S) cryogels infused with honey and to characterize these materials physicochemically, morphologically, and thermally, followed by in vitro analysis of swelling capacity, degradation/weight loss, honey delivery kinetics, and possible activity against Staphylococcus aureus. The addition of honey to PVA led to many PVA crystals with defects, while PVA–starch–honey and PVA–sodium carboxymethylcellulose–honey (PVA-CMC-H) formed amorphous gels. PVA-CMC presented the highest swelling degree of all. PVA-CMC-H and PVA–gelatin–honey presented the highest swelling capacities of the honey-laden samples. Weight loss/degradation was significantly higher for samples containing honey. Layers submitted to more freeze–thawing cycles were less porous in SEM images. With the honey concentration used, samples did not inhibit S. aureus, but pure manuka honey was bactericidal and dilutions superior to 25% honey were bacteriostatic, indicating the need for higher concentrations to be more effective.

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Section: Introductionmentioning

confidence: 99%

Physically Cross-Linked Gels of PVA with Natural Polymers as Matrices for Manuka Honey Release in Wound-Care Applications

Santos

Moreira²,

Carvalho

et al. 2019

Materials

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“…The obtained PAAm/CNF DN gels present notably improved mechanical properties that are proper for application as biomedical load-bearing gel materials [126]. Hydrogels based on PVA blended with cellulose (PVA-Cel) were obtained through FT cycles and were evaluated in terms of appropriateness as a part of a structure simulating the length scale dependence of human skin [123]. CMC-PEO hydrogels and porous gel films, with excellent biocompatibility, were prepared by mixing CMC-acrylate and PEO-hexa-thiols, as precursor PAAm/cellulose nanofibers (CNF) DN gels were synthesized by simply using an alkali treatment (15 wt % NaOH) at room temperature.…”

Section: Graft-copolymerizationmentioning

confidence: 99%

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Vasile¹,

Pamfil²,

Stoleru³

et al. 2020

Molecules

179

131

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New trends in biomedical applications of the hybrid polymeric hydrogels, obtained by combining natural polymers with synthetic ones, have been reviewed. Homopolysaccharides, heteropolysaccharides, as well as polypeptides, proteins and nucleic acids, are presented from the point of view of their ability to form hydrogels with synthetic polymers, the preparation procedures for polymeric organic hybrid hydrogels, general physico-chemical properties and main biomedical applications (i.e., tissue engineering, wound dressing, drug delivery, etc.).

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Fabrication and characterization of PVA-based green materials

Parhi

2021

Advanced Green Materials

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A tribo-mechanical analysis of PVA-based building-blocks for implementation in a 2-layered skin model

Cited by 9 publications

References 67 publications

Physically Cross-Linked Gels of PVA with Natural Polymers as Matrices for Manuka Honey Release in Wound-Care Applications

Physically Cross-Linked Gels of PVA with Natural Polymers as Matrices for Manuka Honey Release in Wound-Care Applications

New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers

Fabrication and characterization of PVA-based green materials

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