A Trial of Short Incubation, Broad-Area Photodynamic Therapy for Facial Actinic Keratoses and Diffuse Photodamage

Randomized Vehicle-Controlled Study of Short Drug Incubation Aminolevulinic Acid Photodynamic Therapy for Actinic Keratoses of the Face or Scalp

“…The results of this study confirm and extend the results of previous smaller studies 7,8 showing that blue light ALA-PDT performed using incubation times as short as 1 hour can provide significant clearance of AKs. Although a single short-incubation ALA-PDT treatment in this study produced lesion clearance from 36% to 57%, a second treatment performed at Week 8 increased the AKCR to 68% to 79% (Table 1).…”

De fotodynamische behandeling van een oppervlakkig plaveiselcelcarcinoom van de neusspiegel bij een kat

“…There also was an excellent cosmetic result, thanks to the small amount of crust formation. In accordance with some studies (Reeds et al , 2004) and in contradiction to others (Peaston et al , 1993;Frimberger et al, 1998;Stell et al , 2001;Touma et al, 2004), this study did not reveal adverse effects such as local discomfort, lack of appetite or vomiting. Thanks to the topical use of the cream, systemic effects and generalized photosensitization leading to cutaneous sensitivity, which has been noted in cases of intravenously administered photosensitizing agent (Hahn et al, 1998), was absent and the cat could be exposed to sunlight within 24 hours after the treatment (Savary et al , 1998;Maier et al, 2001).…”

delta-Aminolevulinic Acid and Blue Light Photodynamic Therapy for Treatment of Multiple Basal Cell Carcinomas in Two Patients with Nevoid Basal Cell Carcinoma Syndrome

“…A small study of the broad-area photodynamic therapy with d-aminolevulinic acid for diffuse facial photoaging and actinic keratoses recently conducted in our institution revealed safety and efficacy for actinic keratoses as well as significant improvement in facial ephelides, rhytides, and other markers of photodamage. 16 Decreased wrinkling is consistent with the histologic observation made by Fink-Puches et al 2 that at 36 months after therapy photodynamic therapy with d-aminolevulinic acid produced dermal fibrosis (but not clinical scarring) significantly deeper than the thickness of the treated basal cell carcinomas. Recent in vitro investigations of Karrer et al 17 have demonstrated that cultures of scleroderma fibroblasts treated with photodynamic therapy with d-aminolevulinic acid had significantly increased levels of matrix metalloproteinases 1 and 3 and decreased levels of collagen type I mRNA, observations that offer a possible mechanism for clinical softening of skin in scleroderma patients after the treatment with topical photodynamic therapy.…”