A translational murine model of aseptic loosening with osseointegration failure
Andrew L. Thomson,
Vincentius J. Suhardi,
Yingzhen Niu
et al.
Abstract:An in vivo animal model of a weight‐bearing intra‐articular implant is crucial to the study of implant osseointegration and aseptic loosening caused by osseointegration failure. Osseointegration, defined as a direct structural and functional attachment between living bone tissue and the surface of a load‐carrying implant, is essential for implant stability and considered a prerequisite for the long‐term clinical success of implants in total joint arthroplasty. Compared to large animal models, murine models off… Show more
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