2019
DOI: 10.26434/chemrxiv.9795338
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A Transient Directing Group Strategy Enables Enantioselective Reductive Heck Hydroarylation of Alkenes

Abstract: <p>Metal-coordinating directing groups have seen extensive use in the field of transition-metal-mediated functionalization of alkenes; however, their waste-generating installation and removal steps limit the efficiency and practicality of reactions that rely on their use. Inspired by developments in the field of C–H activation, herein we report a transient directing group approach to reductive Heck hydroarylation of alkenyl benzaldehyde substrates that proceeds under mild conditions. Highly stereoselecti… Show more

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