A transient decrease in mitochondrial activity contributes to establish the ganglion cell fate in retina adapted for high acuity vision

Brodier, Laurent; Rodrigues, Tania; Matter-Sadzinski, Lidia; Matter, Jean‐Marc

doi:10.1016/j.ydbio.2020.10.002

Cited by 5 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, a critical determinant of an RGC fate is the TF Atoh7, which has a conserved role across species. In chick retina, Atoh7 transactivates Hes5.3 in RPCs that become committed to a ganglion cell fate ( Brodier et al, 2021 ). Strikingly, mitochondrial number is reduced in Hes5.3 expressing RPCs when RGCs begin to differentiate, correlating with reduced PGC1-α expression, a TF that drives mitochondrial biogenesis ( Brodier et al, 2021 ).…”

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

“…In chick retina, Atoh7 transactivates Hes5.3 in RPCs that become committed to a ganglion cell fate ( Brodier et al, 2021 ). Strikingly, mitochondrial number is reduced in Hes5.3 expressing RPCs when RGCs begin to differentiate, correlating with reduced PGC1-α expression, a TF that drives mitochondrial biogenesis ( Brodier et al, 2021 ). Accordingly, the authors propose that reduced mitochondrial activity may slow down the cell cycle long enough for Atoh7 to induce a ganglion cell fate ( Brodier et al, 2021 ).…”

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

“…Strikingly, mitochondrial number is reduced in Hes5.3 expressing RPCs when RGCs begin to differentiate, correlating with reduced PGC1-α expression, a TF that drives mitochondrial biogenesis ( Brodier et al, 2021 ). Accordingly, the authors propose that reduced mitochondrial activity may slow down the cell cycle long enough for Atoh7 to induce a ganglion cell fate ( Brodier et al, 2021 ). This model is in accordance with the cell cycle length hypothesis, which states that progenitor cells poised to differentiate have longer cell cycles so that exposure times to lineage-specifying TFs are increased ( Dalton, 2015 ).…”

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

“…This model is in accordance with the cell cycle length hypothesis, which states that progenitor cells poised to differentiate have longer cell cycles so that exposure times to lineage-specifying TFs are increased ( Dalton, 2015 ). To test this model, Brodier et al (2021) treated chick retinas with FCCP, a mitochondrial uncoupler that binds to protons and equilibrates them across the IMM, thereby dissipating the proton gradient ( Brodier et al, 2021 ). The resulting mitochondrial uncoupling not only increases RPC cell cycle length, but also increases the number of RPCs expressing high levels of Atoh7, a readout of ganglion cell fate commitment ( Brodier et al, 2021 ).…”

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

“…To test this model, Brodier et al (2021) treated chick retinas with FCCP, a mitochondrial uncoupler that binds to protons and equilibrates them across the IMM, thereby dissipating the proton gradient ( Brodier et al, 2021 ). The resulting mitochondrial uncoupling not only increases RPC cell cycle length, but also increases the number of RPCs expressing high levels of Atoh7, a readout of ganglion cell fate commitment ( Brodier et al, 2021 ). Notably, in this chick study, mitophagy is not detected ( Esteban-Martínez et al, 2017 ).…”

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

See 4 more Smart Citations

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Hanna

David

Touahri

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Vision commences in the retina with rod and cone photoreceptors that detect and convert light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative disease leads to visual impairment and blindness. Interventions now in development include transplanting photoreceptors, committed photoreceptor precursors, or retinal pigment epithelial (RPE) cells, with the latter protecting photoreceptors from dying. However, introducing exogenous human cells in a clinical setting faces both regulatory and supply chain hurdles. Recent work has shown that abnormalities in central cell metabolism pathways are an underlying feature of most neurodegenerative disorders, including those in the retina. Reversal of key metabolic alterations to drive retinal repair thus represents a novel strategy to treat vision loss based on cell regeneration. Here, we review the connection between photoreceptor degeneration and alterations in cell metabolism, along with new insights into how metabolic reprogramming drives both retinal development and repair following damage. The potential impact of metabolic reprogramming on retinal regeneration is also discussed, specifically in the context of how metabolic switches drive both retinal development and the activation of retinal glial cells known as Müller glia. Müller glia display latent regenerative properties in teleost fish, however, their capacity to regenerate new photoreceptors has been lost in mammals. Thus, re-activating the regenerative properties of Müller glia in mammals represents an exciting new area that integrates research into developmental cues, central metabolism, disease mechanisms, and glial cell biology. In addition, we discuss this work in relation to the latest insights gleaned from other tissues (brain, muscle) and regenerative species (zebrafish).

show abstract

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

Section: Metabolism and Photoreceptor Developmentmentioning

confidence: 99%

See 3 more Smart Citations

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Hanna

David

Touahri

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Increased neuron density in the midbrain of a foveate bird, pigeon, results from profound change in tissue morphogenesis

Rodrigues

Dib

Bréthaut³

et al. 2023

Developmental Biology

View full text Add to dashboard Cite

Increased neuron density in the midbrain of foveate birds results from profound change in tissue morphogenesis

Rodrigues

Dib

Bréthaut³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

The increase of brain neuron number in relation with brain size is currently considered to be the major evolutionary path to high cognitive power in amniotes. However, how changes in neuron density did contribute to the evolution of the information-processing capacity of the brain remains unanswered. High neuron densities are seen as the main reason why the fovea located at the optical center of the retina is responsible for sharp vision in birds and primates. The emergence of foveal vision is considered as a breakthrough innovation in visual system evolution. We found that neuron densities in the largest visual center of the midbrain, i.e., the optic tectum, are two to four times higher in modern birds with one or two foveae compared to birds deprived of this specialty. Interspecies comparisons enabled us to identify elements of a hitherto unknown developmental process set up by foveate birds for increasing neuron density in the upper layers of their optic tectum. The progenitor cells that generate these neurons proliferate in a ventricular zone that can expand only radially. In this particular context, the number of cells in ontogenetic columns increases, thereby setting the conditions for higher cell densities in the upper layers once neurons did migrate.

show abstract

A transient decrease in mitochondrial activity contributes to establish the ganglion cell fate in retina adapted for high acuity vision

Cited by 5 publications

References 57 publications

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair

Increased neuron density in the midbrain of a foveate bird, pigeon, results from profound change in tissue morphogenesis

Increased neuron density in the midbrain of foveate birds results from profound change in tissue morphogenesis

Contact Info

Product

Resources

About