A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

Choi, Yeon Sik; Jeong, Hyoyoung; Yin, Rose T.; Avila, Raudel; Pfenniger, Anna; Yoo, Jae-Young; Lee, Jong Yoon; Tzavelis, Andreas; Lee, Young Joong; Chen, Sheena W.; Knight, Bradley; Kim, Seung Yeob; Ahn, Hak-Young; Wickerson, Grace; Vázquez‐Guardado, Abraham; Dempsey, Elizabeth; Russo, B; Napolitano, Michael A.; Holleran, Timothy J.; Razzak, Leen Abdul; Miniovich, Alana N.; Lee, Geumbee; Geist, Beth; Kim, Brandon; Han, Shuling; Brennan, Jaclyn A.; Aras, Kedar; Kwak, Sung Soo; Kim, Joohee; Waters, Emily A.; Yang, Xiangxing; Burrell, Amy; Chun, Keum San; Liu, Claire; Wu, Changsheng; Rwei, Alina Y.; Spann, Alisha N; Banks, Anthony; Johnson, David A.; Zhang, Zheng Jenny; Haney, Chad R.; Jin, Sung Hun; Sahakian, Alan V.; Huang, Yonggang; Trachiotis, Gregory D.; Knight, Bradley P.; Arora, Rishi; Efimov, Igor R.; Rogers, John A.

doi:10.1126/science.abm1703

Cited by 103 publications

(97 citation statements)

References 45 publications

(22 reference statements)

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“…The soft bioelectronics tools specifically made for cardiovascular applications have enabled more profound understanding of cardiac physiology and play an important role in clinical diagnosis and treatment of diseases such as metabolic dysfunction, heart failure, and arrhythmia 11,[16][17][18][19] . Several considerable achievements have been reported, such as optogenetic cardiac pacing via a fully implantable battery-free pacemaker 16 , cardiac ablation via a catheter-integrated multi-functional soft electronic array 17 , and bioresorbable transient pacemaker controlled by a wearable device network 18,20,21 .…”

Section: Introductionmentioning

confidence: 99%

Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment

Lin

Kireev

Liu

et al. 2022

Preprint

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The human heart is an efficient electromechanical pump which provides oxygen and nutrients to all human organs. Each heartbeat is ignited and synchronized by an electrical action potential initiating and rapidly propagating through the heart's electrical system. Cardiovascular diseases, a leading cause of death in humans, disrupt this synchronous excitation. Heart rhythm disorders, known as arrhythmias, are particularly deadly. Cardiac arrhythmias are primarily treated by implantable pacemakers and defibrillators because pharmacological treatments are mostly ineffective. In this work, we report on graphene-only cardiac pacemakers as advanced cardiac biointerfaces. Leveraging sub-micrometer thick tissue-conformable graphene arrays, we are able to sense from and stimulate the heart, altering its functions, suggesting that the devices can be used for high-density functional interfacing with the heart. The arrays show effective electrochemical properties, namely interface impedance down to 40 Ohm x cm2, charge storage capacity up to 63.7 mC/cm2, and charge injection capacity up to 704 uC/cm2. Transparency of the structures allows for simultaneous optical mapping of cardiac action potentials and calcium transients while performing electrical measurements. Upon validating the graphene-based cardiac pacing in ex vivo mouse hearts, we performed in vivo cardiac pacing in a rat model with clinically induced arrhythmia. The condition was successfully diagnosed and treated using graphene biointerfaces.

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Section: Introductionmentioning

confidence: 99%

Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment

Lin

Kireev

Liu

et al. 2022

Preprint

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“…This device can be applied for biomedical applications including but not limited to neural regeneration, wound healing, and cardiac pacemakers. Similar types of devices have been tested on large mammals such as rabbits and canines. , …”

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“…Similar types of devices have been tested on large mammals such as rabbits and canines. 20,48 There are several improvements we could make in the future. The PLGA film swelled once the device was implanted because the body fluid penetrated, triggering the degradation of the device.…”

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confidence: 99%

Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery

Huang

et al. 2022

Nano Lett.

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A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.

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“…As the field progresses, additional capabilities, such as monitoring biological function will be built into bioadhesive materials. 39,40 In this Review, we discuss a broad range of biomaterials and fabrication methods that serve to enhance cohesion and adhesion, along with their advantages and shortcomings. As illustrated in Fig.…”

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confidence: 99%

“…As the field progresses, additional capabilities, such as monitoring biological function will be built into bioadhesive materials. 39,40…”

mentioning

confidence: 99%