Abstract. In secondary data use context, traditional data warehouse design methods don't address many of today's challenges; particularly in the healthcare domain were semantics plays an essential role to achieve an effective and implementable heterogeneous data integration while satisfying core requirements. Forty papers were selected based on seven core requirements: data integrity, sound temporal schema design, query expressiveness, heterogeneous data integration, knowledge/source evolution integration, traceability and guided automation. Proposed methods were compared based on twenty-two comparison criteria. Analysis of the results shows important trends and challenges, among them (1) a growing number of methods unify knowledge with source structure to obtain a well-defined data warehouse schema built on semantic integration; (2) none of the published methods cover all the core requirements as a whole and (3) their potential in real world is not demonstrated yet.