A Transdermal Measurement Platform Based on Microfluidics

Wen-ying, Huang; Huang, Jung-Ping; Lin, Chia-Ching; Lin, Yung‐Sheng

doi:10.1155/2017/9343824

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…As mentioned earlier, the Franz diffusion cell allows us to analyse five samples in a single run, whereas the customised Franz-type cell setup permits running 20 samples simultaneously and can be customised to specific analysis requirements. Moreover, it offers a larger surface area for diffusion which makes sample application, assuming the same level of competency when using both apparatuses, much easier and assists in avoiding air bubble formation, which otherwise might interfere with the diffusion leading to inaccurate results [ 20 , 21 , 22 , 23 , 24 , 25 ]. An additional benefit is related to accessibility because any lab could devise the customised Franz cell whereas not every lab has access to the commercial Franz cell setup.…”

Section: Discussionmentioning

confidence: 99%

Application of a Customised Franz-Type Cell Coupled with HPTLC to Monitor the Timed Release of Bioactive Components in Complex Honey Matrices

Hossain

Nguyen

Benington

et al. 2023

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The aim of this study was to assess the release profile of components in five different honeys (a New Zealand Manuka and two Western Australian honeys, a Jarrah honey and a Coastal Peppermint honey) and their corresponding honey-loaded gel formulations using a custom-designed Franz-type diffusion cell in combination with High-Performance Thin-Layer Chromatography (HPTLC). To validate the suitability of the customised setup, release data using this new approach were compared with data obtained using a commercial Franz cell apparatus, which is an established analytical tool to monitor the release of active ingredients from topical semisolid products. The release profiles of active compounds from pure honey and honey-loaded formulations were found to be comparable in both types of Franz cells. For example, when released either from pure honey or its corresponding pre-gel formulation, the percentage release of two Jarrah honey constituents, represented by distinct bands at RF 0.21 and 0.53 and as analysed by HPTLC, was not significantly different (p = 0.9986) at 12 h with over 99% of these honey constituents being released in both apparatus. Compared to the commercial Franz diffusion cell, the customised Franz cell offers several advantages, including easy and convenient sample application, the requirement of only small sample quantities, a large diffusion surface area, an ability to analyse 20 samples in a single experiment, and lower cost compared to purchasing a commercial Franz cell. Thus, the newly developed approach coupled with HPTLC is conducive to monitor the release profile of minor honey constituents from pure honeys and honey-loaded semisolid formulations and might also be applicable to other complex natural-product-based products.

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Section: Discussionmentioning

confidence: 99%

Application of a Customised Franz-Type Cell Coupled with HPTLC to Monitor the Timed Release of Bioactive Components in Complex Honey Matrices

Hossain

Nguyen

Benington

et al. 2023

MPs

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Skin models of cutaneous toxicity, transdermal transport and wound repair

et al. 2023

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Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive molecules. However, the barrier properties of the skin, along with its multilayer structure, impose severe restrictions on drug transport and bioavailability. Thus, bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin wounds. Even though in vivo research is often preferred to study biological processes involving the skin, in vitro and ex vivo strategies have been gaining increasing relevance in recent years. Indeed, there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted guidelines. Furthermore, microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin emulation. Challenges in miniaturization, automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust, high-throughput manner, while being compliant with regulatory issues, standards and guidelines. In this review, skin models for transdermal transport, wound repair and cutaneous toxicity will be discussed with a focus on high-throughput strategies. Novel microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models, both in terms of complexity and throughput.

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A Transdermal Measurement Platform Based on Microfluidics

Cited by 2 publications

References 35 publications

Application of a Customised Franz-Type Cell Coupled with HPTLC to Monitor the Timed Release of Bioactive Components in Complex Honey Matrices

Application of a Customised Franz-Type Cell Coupled with HPTLC to Monitor the Timed Release of Bioactive Components in Complex Honey Matrices

Skin models of cutaneous toxicity, transdermal transport and wound repair

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