A transcutaneous implantable bladder controller

Duval, F.; Hassouna, Magdy; Li, J. S.; Elhilali, Mostafa

doi:10.1002/nau.1930120313

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…One striking example of the knowledge gained from canine experiments is sacral nerve stimulation, described in the 19,000 and later in several studies (83,87,88). This technique was very successful and translated from bench to bed in <15 years following work from Brindley who developed a human sacral anterior root stimulator (89).…”

Section: Functional Electrical Stimulationmentioning

confidence: 99%

Bladder and Bowel Management in Dogs With Spinal Cord Injury

2020

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Spinal cord injury in companion dogs can lead to urinary and fecal incontinence or retention, depending on the severity, and localization of the lesion along the canine nervous system. The bladder and gastrointestinal dysfunction caused by lesions of the autonomic system can be difficult to recognize, interpret and are easily overlooked. Nevertheless, it is crucial to maintain a high degree of awareness of the impact of micturition and defecation disturbances on the animal's condition, welfare and on the owner. The management of these disabilities is all the more challenging that the autonomic nervous system physiology is a complex topic. In this review, we propose to briefly remind the reader the physiology of micturition and defecation in dogs. We then present the bladder and gastrointestinal clinical signs associated with sacral lesions (i.e., the L7-S3 spinal cord segments and nerves) and supra-sacral lesions (i.e., cranial to the L7 spinal cord segment), largely in the context of intervertebral disc herniation. We summarize what is known about the natural recovery of urinary and fecal continence in dogs after spinal cord injury. In particular we review the incidence of urinary tract infection after injury. We finally explore the past and recent literature describing management of urinary and fecal dysfunction in the acute and chronic phase of spinal cord injury. This comprises medical therapies but importantly a number of surgical options, some known for decades such as sacral nerve stimulation, that might spark some interest in the field of spinal cord injury in companion dogs.

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Section: Functional Electrical Stimulationmentioning

confidence: 99%

Bladder and Bowel Management in Dogs With Spinal Cord Injury

2020

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“…Various approaches to improve bladder function and restore normal continence have been tested in dogs, including transcutaneous bladder stimulation [ 192 ], as well as pelvic [ 193 ] and pudendal nerve stimulation [ 191 , 194 ] and intraspinal sacral root stimulation [ 139 ]. Bladder atony at the time of spinal shock was improved via the functional electrical stimulation of sacral nerve roots [ 44 , 140 ] when delivered to dogs early in the disease process.…”

Section: Cystometric Findings In Animal Models Of Scimentioning

confidence: 99%

Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical Neuro-Urology Research

et al. 2023

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Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding function and remains one of the leading causes of morbidity after spinal cord injury (SCI). The vast majority of individuals with severe SCI develop neurogenic lower urinary tract dysfunction (NLUTD), with symptoms ranging from neurogenic detrusor overactivity, detrusor sphincter dyssynergia, or sphincter underactivity depending on the location and extent of the spinal lesion. Animal models are critical to our fundamental understanding of lower urinary tract function and its dysfunction after SCI, in addition to providing a platform for the assessment of potential therapies. Given the need to develop and evaluate novel assessment tools, as well as therapeutic approaches in animal models of SCI prior to human translation, urodynamics assessment techniques have been implemented to measure NLUTD function in a variety of animals, including rats, mice, cats, dogs and pigs. In this narrative review, we summarize the literature on the use of animal models for cystometry testing in the assessment of SCI-related NLUTD. We also discuss the advantages and disadvantages of various animal models, and opportunities for future research.

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A transcutaneous implantable bladder controller

Cited by 2 publications

References 3 publications

Bladder and Bowel Management in Dogs With Spinal Cord Injury

Bladder and Bowel Management in Dogs With Spinal Cord Injury

Assessing Neurogenic Lower Urinary Tract Dysfunction after Spinal Cord Injury: Animal Models in Preclinical Neuro-Urology Research

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