A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of<i>C. elegans</i>

Chang, Shih-sen; Johnston, Robert J.; Hobert, Oliver

doi:10.1101/gad.1117903

Cited by 158 publications

(233 citation statements)

References 39 publications

(67 reference statements)

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“…In addition to autoregulation, we identified two more genes that are required to maintain die-1 expression in ASEL. Animals that lack the ceh-36 homeobox gene, a previously identified regulator of ASEL identity (Chang et al 2003) that is expressed in both ASEL and ASER (Supplemental Fig. S1), show normal ASEL-restricted expression of die-1 in early developmental stages but lose die-1 expression in later stages (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1; Sagasti et al 2001;Chuang and Bargmann 2005). However, none of these mechanisms operate in the establishment of ASE asymmetry (Chang et al 2003). Left/right asymmetry of the two ASE neurons is rather conferred by a Notch-dependent signaling event in the early embryo that establishes a specific chromatin state at a microRNA (miRNA) locus, lsy-6, in the precursors of the left ASE neuron (Poole and Hobert 2006;Cochella and Hobert 2012).…”

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confidence: 99%

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Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1

et al. 2013

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Left/right asymmetric features of animals are either randomly distributed on either the left or right side within a population (''antisymmetries'') or found stereotypically on one particular side of an animal (''directional asymmetries''). Both types of asymmetries can be found in nervous systems, but whether the regulatory programs that establish these asymmetries share any mechanistic features is not known. We describe here an unprecedented molecular link between these two types of asymmetries in Caenorhabditis elegans. The zinc finger transcription factor die-1 is expressed in a directionally asymmetric manner in the gustatory neuron pair ASE left (ASEL) and ASE right (ASER), while it is expressed in an antisymmetric manner in the olfactory neuron pair AWC left (AWCL) and AWC right (AWCR). Asymmetric die-1 expression is controlled in a fundamentally distinct manner in these two neuron pairs. Importantly, asymmetric die-1 expression controls the directionally asymmetric expression of gustatory receptor proteins in the ASE neurons and the antisymmetric expression of olfactory receptor proteins in the AWC neurons. These asymmetries serve to increase the ability of the animal to discriminate distinct chemosensory inputs.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1

et al. 2013

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“…zMOZ-dependent expression of Hox proteins such as Hoxa2a and Hoxa2b controls segment-specific fate maps of facial skeletal precursors. Related to this, Hoxa2 is important for development of mouse facial somatosensory map (Oury et al, 2006) and Lin49 controls Hox-C expression in C. elegans (Chamberlin and Chang et al, 2003). All of these suggest that zMOZ is important for skeletogenesis in zebrafish.…”

Section: Moz and Morf In Mouse And Zebrafish Developmentmentioning

confidence: 95%

“…Related to this, Enok is required for mushroom body formation in fly brain (Scott et al, 2001). Moreover, the BRPF ortholog Lin49 in C. elegans (Figure 2b) is part of a transcriptional hierarchy important for the control of left/right asymmetry in chemosensory neurons (Chamberlin and Thomas, 2000;Chang et al, 2003). The craniofacial abnormalities of Querkopf mice are in part due to defects in calvarial bones .…”

Section: Moz and Morf In Mouse And Zebrafish Developmentmentioning

confidence: 99%

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

2007

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Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3) and its paralog MORF (MYST4) are rearranged in chromosome translocations associated with acute myeloid leukemia and/or benign uterine leiomyomata. Both proteins have intrinsic histone acetyltransferase activity and are components of quartet complexes with noncatalytic subunits containing the bromodomain, plant homeodomain-linked (PHD) finger and proline-tryptophan-tryptophan-proline (PWWP)-containing domain, three types of structural modules characteristic of chromatin regulators. Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity.

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“…On the other hand, while both the left and right AWC neurons sense benzaldehyde, either the left or the right AWC neuron responds to the volatile odorant butanone, and the other neuron responds to 2,3-pentanedione [71,99] (Table 1). The advantages of assigning the sensory functions stochastically as in the AWC neurons [100], or via a developmentally hardwired mechanism as for the ASE neurons [101][102][103] is not immediately obvious. A suggestion from these findings is that other chemosensory neuron types are likely to also exhibit left/right functional diversification, essentially doubling the sensory neuron repertoire.…”

Section: Mapping Chemicals To Chemosensory Neuronsmentioning

confidence: 99%

Generation and modulation of chemosensory behaviors in C. elegans

Sengupta

2007

Pflugers Arch - Eur J Physiol

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C. elegans recognizes and discriminates among hundreds of chemical cues using a relatively compact chemosensory nervous system. Chemosensory behaviors are also modulated by prior experience and contextual cues. Because of the facile genetics and genomics possible in this organism, C. elegans provides an excellent system in which to explore the generation of chemosensory behaviors from the level of a single gene to the motor output. This review summarizes the current knowledge on the molecular and neuronal substrates of chemosensory behaviors and chemosensory behavioral plasticity in C. elegans.

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A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons ofC. elegans

Abstract: [Keywords: C. elegans; left/right asymmetry; transcription factor; homeobox] Supplemental material is available at http://www.genesdev.org.

Cited by 158 publications

References 39 publications

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1

Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

Generation and modulation of chemosensory behaviors in C. elegans

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