A Transcriptional Regulation Bioinformatics Pipeline to Predict Co‐Regulated Genes in Vascular Smooth Muscle Cell Phenotypic Transitions During Atherosclerosis
Abstract:The rupture of vulnerable or advanced atherosclerotic lesions contributes to myocardial infarctions and strokes, the leading causes of death globally. During all stages of atherosclerosis, vascular smooth muscle cells (VSMCs) are recruited as a major source of plaque cells within lesions, where they undergo phenotypic modulation and give rise to both plaque‐stabilizing and destabilizing phenotypes. Because most atherosclerosis studies test the functional role of single transcription factors, genes, and protein… Show more
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