A transcription factor response element for gene expression during circadian night

Ueda, Hiroki R.; Chen, Wenbin; Adachi, Ayumi; Wakamatsu, Hisanori; Hayashi, Satoko; Takasugi, Tomohiro; Nagano, Mamoru; Nakahama, Ken-ichi; Suzuki, Yutaka; Sugano, Sumio; Iino, Masamitsu; Shigeyoshi, Yasufumi; Hashimoto, Seiichi

doi:10.1038/nature00906

Cited by 782 publications

(726 citation statements)

References 28 publications

Supporting

Mentioning

669

Contrasting

Unclassified

Order By: Relevance

“…Each study has employed a different plat form, data analysis methods, and screened different numbers of genes. In general, it appears that about 10 % of the genes are circadianly expressed in the liver, heart, and kidneys (Akhtar et al, 2002;Kita et al, 2002;Panda et al, 2002;Storch et al, 2002;Ueda et al, 2002). Interestingly, in the fibroblasts it has been reported that fewer than 100 genes (or about 2% of the genes present in these cells) are rhythmically expressed (Duffield et al, 2002;Grundschober et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…In the recent years, the DNA microarray technique has been successfully used to study circadian gene expression in the SCN, liver, heart, kidney, and fibroblasts (Grundschober et al, 2001;Akhtar et al, 2002;Duffield et al, 2002;Kita et al, 2002;Panda et al, 2002;Storch et al, 2002;Ueda et al, 2002). The picture that is emerging from these studies indicates that in each tissue or organ a certain number of genes (approximately 2-10 %) are under circadian control.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of daily and circadian gene expression in the rat pineal gland

Fukuhara¹,

Tosini²

2008

Neuroscience Research

View full text Add to dashboard Cite

The mammalian pineal gland is an important component of the circadian system. In the present study, we examined the expression of roughly 8000 genes in the rat pineal gland as a function of time of day under light-dark (LD) cycles and in constant dark (DD) using oligo DNA microarray technique. We identified 47 and 13 genes that showed higher levels at night and day, respectively, under LD. The same patterns of expression were also observed in DD. About half of the genes that peaked at night have a known biological function, i.e., transcription factors and proteins that are involved in signaling cascades, whereas 14 are expressed sequence tags and 8 have an unknown biological function. Twelve of the genes that are up-regulated at night were also up-regulated after 1 h NE stimulation, thus suggesting that the expression of these genes is controlled by adrenergic mechanisms. Of the 13 genes that were up-regulated in the daytime, 6 coded for proteins that are involved in intracellular signaling pathways. The results obtained with microarray analysis were well correlated with data obtained using real time quantitative RT-PCR. The present results provide new materials to dissect and understand the pineal physiology.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of daily and circadian gene expression in the rat pineal gland

Fukuhara¹,

Tosini²

2008

Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…Components of a molecular clock underlying rhythmic gene expression have been characterized in neurons of the suprachiasmatic nucleus (SCN) [23,24], in liver [23][24][25][26][27], heart [26], synchronized fibroblasts [28], adipose tissue [29], adrenal gland [30], skeletal muscle [31], pituitary [32] and pineal [33] glands, calvarial bone [34], as well as in epithelial cells of lung [35,36] and gastrointestinal tract [37][38][39]. In order to ensure proper temporal organization in metabolism and behavior at the level of an organism, the multiple tissue-specific transcriptional oscillations have to be synchronized with the natural 24-hr cycle.…”

Section: Circadian Clock Organizationmentioning

confidence: 99%

Pharmacological modulators of the circadian clock as potential therapeutic drugs

Antoch

Chernov

2009

Mutation Research/Genetic Toxicology and Environmental Mutagene

View full text Add to dashboard Cite

Circadian clocks are molecular time-keeping systems that underlie daily fluctuations in multiple physiological and biochemical processes. It is well recognized now that dysfunctions of the circadian system (both genetically and environmentally induced) are associated with the development of various pathological conditions. Here we describe the application of high throughput screening approach designed to search for small molecules capable of pharmacological modulation of the molecular clock. We provide evidence for the feasibility and value of this approach for both scientific and therapeutic purposes.

show abstract

“…CCGs maintain a predictable phase relationship with the core clock genes (Ueda et al, 2002), indicating that the CCGs are either directly or indirectly regulated via the circadian transcriptional machinery. The expression of some CCGs is directly controlled by the CLOCK:BMAL1 heterodimer binding to an E-box enhancer (CACGTG) in their promoter (Jin et al, 1999).…”

Section: Direct Transcriptional Controlmentioning

confidence: 99%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

View full text Add to dashboard Cite

Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

show abstract

A transcription factor response element for gene expression during circadian night

Cited by 782 publications

References 28 publications

Analysis of daily and circadian gene expression in the rat pineal gland

Analysis of daily and circadian gene expression in the rat pineal gland

Pharmacological modulators of the circadian clock as potential therapeutic drugs

The regulation of neuroendocrine function: Timing is everything

Contact Info

Product

Resources

About