A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
Horacio Maldonado,
Marcel Dreger,
Katarzyna Wolanska
et al.
Abstract:HER2 and αVβ6 integrin are independent predictors of breast cancer survival and metastasis. We investigated αVβ6 signalling and identified an αVβ6/HER2 crosstalk mechanism, which drives invasion and is dysregulated in drug resistant HER2+ breast cancer cells. Proteomic approaches revealed ligand-bound αVβ6 recruits HER2 and a trafficking regulatory subnetwork comprising the small GTPases RAB5 and RAB7A, and the Rab regulator GDI2. We show that the RAB5/RAB7A/GDI2 functional module mediates direct crosstalk bet… Show more
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