A traditional Chinese medicine JiuHuangLian (Rhizoma coptidis steamed with rice wine) reduces oxidative stress injury in type 2 diabetic rats

Jia-chuan, LI; Shen, Xiaofei; Meng, Xianli

doi:10.1016/j.fct.2013.06.005

Cited by 25 publications

(18 citation statements)

References 31 publications

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“…Induction of type 2 diabetes was performed as per our previous method 14. In brief, diabetes was induced in the rats by intraperitoneal injection of a single dose of 40 mg/kg STZ freshly dissolved in citrate buffer.…”

Section: Methodsmentioning

confidence: 99%

“…For example, Acorus tatarinowii and its main active components α-asarone and β-asarone have been demonstrated to be effective in experimental models of cognitive deficits 11–1314. Our previous results showed that the extract from C. chinensis exhibited significant antidiabetic effect in streptozotocin (STZ)- and high-glucose/high-fat diet-induced diabetic rats through antioxidant and pancreatic β-cell protection 14.…”

Section: Introductionmentioning

confidence: 99%

“…Coptis chinensis Franch, a famous Chinese herbal medicine, has been used for thousand years to treat diabetes and related complications in China, Japan, and Korea 14. Our previous results showed that the extract from C. chinensis exhibited significant antidiabetic effect in streptozotocin (STZ)- and high-glucose/high-fat diet-induced diabetic rats through antioxidant and pancreatic β-cell protection 14. Furthermore, the total alkaloids from C. chinensis (TAC) including berberine have also been demonstrated as potential anti-dementia agents 15.…”

Section: Introductionmentioning

confidence: 99%

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The total alkaloids from <em>Coptis chinensis</em> Franch improve cognitive deficits in type 2 diabetic rats

Jia-chuan

Shen

Shao

et al. 2018

DDDT

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BackgroundCoptis chinensis Franch is extensively used in traditional Chinese medicine to treat diabetes and dementia. Alkaloids are the main active ingredients of C. chinensis.PurposeThis study was designed to probe the effects and possible mechanisms of the total alkaloids from C. chinensis (TAC) on cognitive deficits in type 2 diabetic rats.MethodsCognitive deficits were induced in rats by streptozotocin and high glucose/high fat diet. After treatment with TAC (80, 120, and 180 mg/kg) for 24 weeks, the behavioral parameters of each rat were assessed by Morris water maze and Y-maze tests. The indexes of glucose and lipid metabolism, pathological changes of brain tissue, and the phosphorylation levels of insulin signaling related proteins were also evaluated.ResultsThe type 2 diabetic rats showed significantly elevated levels of fasting blood glucose, glycosylated hemoglobin and glycosylated serum protein, as well as apolipoprotein B, free fatty acid, triglyceride and total cholesterol but decreased the content of apolipoprotein A1, and TAC treatment dose-dependently reversed these abnormal changes. Furthermore, the behavioral results showed that TAC alleviated the cognitive deficits in type 2 diabetic rats. Moreover, immunohistochemical and histopathologic examinations indicated that the diabetic rats showed significant Aβ deposition, and neuronal damage and loss, which can be reversed by TAC treatment. The western blot results showed that TAC treatment markedly increased the phosphorylation of IRS, PI3K, and Akt, and inhibited the overactivation of GSK3β in the brain of type 2 diabetic rats.ConclusionThese findings conclude that TAC prevents diabetic cognitive deficits, most likely by ameliorating the disorder of glucose and lipid metabolism, attenuating Aβ deposition, and enhancing insulin signaling.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The total alkaloids from <em>Coptis chinensis</em> Franch improve cognitive deficits in type 2 diabetic rats

Jia-chuan

Shen

Shao

et al. 2018

DDDT

Self Cite

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“…Meanwhile, reactive oxygen species (ROS) and free radical-mediated oxidative stress are generated, which may cause various diseases, such as cancer (Valko, Rhodes, Moncol, Izakovic, & Mazur, 2006), Alzheimer's disease (Butterfield, Drake, Pocernich, & Castegna, 2001), cardiovascular diseases (Middleton, Kandaswami, & Theoharides, 2000), and diabetes mellitus (DM) (Giovannini, Piaggi, Federico, & Scarpato, 2014). Growing evidence has indicated that there is a relationship between oxidative stress and DM (Li, Shen, & Meng, 2013;Yang, Jin, Lam, & Yan, 2011). DM is one of the leading causes of death, which has threatened mankind for centuries.…”

Section: Introductionmentioning

confidence: 99%

Bioactives from stems and leaves of mung beans ( Vigna radiata L.)

Bai

Yan

Chang

et al. 2016

Journal of Functional Foods

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“…Chinese rice wine (CRW), a traditional Chinese alcoholic beverage, is consumed widely in China and is commonly used as an ingredient in traditional Chinese medicine prescription guiding drug (Li, Shen, & Meng, 2013). Traditional rice wines are made from sticky rice, wheat, and some medicinal plants or herbs fermented by Chinese koji.…”

Section: Introductionmentioning

confidence: 99%

Antifatigue and antiaging effects of Chinese rice wine in mice

Zhao

Wang

Zhao

et al. 2018

Food Science & Nutrition

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Chinese rice wine (CRW) is widely known for keeping good health and commonly used in the traditional Chinese medicine prescription guiding drug. This study assesses the effects of CRW on antifatigue and antiaging activities in mice models. Mice were randomly divided into four groups performing with 0.25 ml of distilled water, 0.15, 0.25, and 0.4 ml of CRW for 15 consecutive days. The CRW could obviously increase the content of liver glycogen (LG) and decrease the levels of blood lactic acid (BLA)and blood urea nitrogen (BUN) to improve antifatigue ability. In antiaging assay, CRW significantly increased the activity of SOD in liver, the activities of GSH‐Px and CAT in brain cortex, body quality, thymus index, and spleen index, and decreased liver MDA levels, liver total cholesterol content, and AChE levels in hippocampus. The CRW has potent antifatigue ability and could minimize the occurrence of age‐associated disorders.

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A traditional Chinese medicine JiuHuangLian (Rhizoma coptidis steamed with rice wine) reduces oxidative stress injury in type 2 diabetic rats

Cited by 25 publications

References 31 publications

The total alkaloids from <em>Coptis chinensis</em> Franch improve cognitive deficits in type 2 diabetic rats

The total alkaloids from <em>Coptis chinensis</em> Franch improve cognitive deficits in type 2 diabetic rats

Bioactives from stems and leaves of mung beans ( Vigna radiata L.)

Antifatigue and antiaging effects of Chinese rice wine in mice

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