A toxicological evaluation of the effect of Carapa guianensis Aublet on pregnancy in Wistar rats

Costa‐Silva, João Henrique; Lyra, Mariana M. A.; Lima, Cybelle Rolim de; Arruda, Viviane Martins de; Araújo, Alice V.; Ribeiro, A. Ribeiro e; Arruda, Alberto C.; Fraga, M.M.F.R.; Lafayette, Simone S.L.; Wanderley, Almir Gonçalves

doi:10.1016/j.jep.2007.02.004

Cited by 35 publications

(23 citation statements)

References 24 publications

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“…In addition, it was verified that administration of Carapa guianensis seed oil did not bring about any toxic effect on pregnancy in rats (Costa-Silva et al, 2007), suggesting that Carapa guianensis seed oil presents low or absence of abortive effect. In present study, all hematological parameters remained under the reference range for the species (Harkness and Wagner, 1993).…”

Section: Discussionmentioning

confidence: 86%

Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil

Costa‐Silva

Lima

Silva

et al. 2008

Journal of Ethnopharmacology

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102

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Section: Discussionmentioning

confidence: 86%

Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil

Costa‐Silva

Lima

Silva

et al. 2008

Journal of Ethnopharmacology

Self Cite

102

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“…The implantation rate, resorptions, and pre‐ and post‐implantation loss rates were obtained according to the method proposed by Costa‐Silva et al . (). The fertility index was calculated as the ratio between the number of live fetuses and the number of mated females (Vendramini et al ., ).…”

Section: Methodsmentioning

confidence: 97%

Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats

et al. 2017

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Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l-carnitine as an antioxidant substance has been confirmed both in humans and rats. Carnitine, present in testis and epididymis, is involved in sperm maturation. It is also effective in infertility treatment. As a continuation of a previous study, we evaluated whether some spermatic qualitative parameters, DNA integrity, chromatin structure, and fertility status, could be ameliorated by the carnitine treatment in adult rats, which were subsequently exposed to doxorubicin at pre-puberty. Pre-pubertal male rats were distributed into four groups: Sham Control; Doxorubicin; l-carnitine; l-carnitine + Doxorubicin (l-carnitine injected 1 h before doxorubicin). At 100 days of age, all groups were reassigned into two sets: One set was submitted to the evaluation of sperm motility, acrosome integrity, mitochondrial activity, sperm chromatin structure analysis (SCSA), and evaluation of the oxidative stress. The other set of rats was destined to the evaluation of reproductive competence. The percentage of spermatozoa with intact acrosome integrity was higher in the Carnitine+Doxorubicin group when compared with the Doxorubicin group. However, sperm motility and mitochondrial activity were not improved by carnitine pre-treatment. Both values of malondialdehyde and nitrite (indirect measurement of nitric oxide) concentrations were statistically higher in the only doxorubicin-treated group when compared to the Carnitine + Doxorubicin group. Fertility index and implantation rate were lower in Doxorubicin group, when compared to Carnitine + Doxorubicin group. Moreover, the percentage of spermatozoa with damaged DNA was higher in the Doxorubicin-treated group when compared to the Carnitine+Doxorubicin group. l-carnitine, when administered before doxorubicin, partially preserved the acrosome integrity, an important feature related to sperm fertilization ability that positively correlated with the reproductive competence and sperm DNA integrity at adulthood. In conclusion, l-carnitine attenuated the long-term alterations caused by doxorubicin in the germ cells and improved male reproductive capacity in adulthood.

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“…Studies on the systemic toxicity of the oil have been conducted on mice and rats, revealing no disturbing effects, with the exception of slight increments of liver weight and alanine aminotransferase plasma levels [19,45,46].…”

Section: Adverse Effectsmentioning

confidence: 99%

Revisiting Amazonian Plants for Skin Care and Disease

Burlando

Cornara

2017

Cosmetics

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Abstract:This review concerns five species of trees and palm trees that occur as dominant plants in different rainforest areas of the Amazon region. Due to their abundance, these species can be exploited as sustainable sources of botanical materials and include Carapa guianensis Aubl., family Meliaceae; Eperua falcata Aubl., family Fabaceae; Quassia amara L., family Simaroubaceae; and Attalea speciosa Mart. and Oenocarpus bataua Mart., family Arecaceae. For each species, the general features, major constituents, overall medicinal properties, detailed dermatological and skin care applications, and possible harmful effects have been considered. The major products include seed oils from A. speciosa and C. guianensis, fruit oil from O. bataua, and active compounds such as limonoids from C. guianensis, flavonoids from E. falcata, and quassinoids from Q. amara. The dermatologic and cosmetic applications of these plants are growing rapidly but are still widely based on empiric knowledge. Applications include skin rehydration and soothing; anti-inflammatory, antiage, and antiparasite effects; hair care; burn and wound healing; and the amelioration of rosacea and psoriasis conditions. Despite a limited knowledge about their constituents and properties, these species appear as promising sources of bioactive compounds for skin care and health applications. An improvement of knowledge about their properties will provide added value to the exploitation of these forest resources.

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A toxicological evaluation of the effect of Carapa guianensis Aublet on pregnancy in Wistar rats

Cited by 35 publications

References 24 publications

Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil

Acute and subacute toxicity of the Carapa guianensis Aublet (Meliaceae) seed oil

Carnitine partially improves oxidative stress, acrosome integrity, and reproductive competence in doxorubicin‐treated rats

Revisiting Amazonian Plants for Skin Care and Disease

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