“…The complexation process generated some changes in the anti-inflammatory activity, which may be linked to a better bioavailability of the pinostrobin molecule [ 33 , 34 ]. The anti-inflammatory activity of pinostrobin might be explained by a synergistic process in which flavonoids intervene in different active sites, producing an anti-inflammatory and analgesic response, among which we can mention the following, the inhibition of pinostrobin on COX-2 and COX-1 and the role of antioxidants in the anti-inflammatory process activity it exhibits [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. When an inflammatory process is triggered, a broad immune response is generated by a wide variety of cells such as lymphocytes, neutrophils, macrophages, leukocytes, and macrophages, which release a significant number of inflammatory cytokines such as tumor necrosis factor (TNF-α) and interleukins such as IL-1, IL-6, IL-8, IL-12, and interferon (IFN-γ).…”