A topical gel nanoformulation of amphotericin B (AmB) for the treatment of cutaneous leishmaniasis (CL)

Boshrouyeh, Reza; Amari, Samar; Ghandashtani, Mohammad Boshrouyeh; Alavi, Seyed Ebrahim; Shahmabadi, Hasan Ebrahimi

doi:10.1007/s10971-023-06041-w

Cited by 13 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These enhancers include compounds that promote stratum corneum hydration and chemical penetration enhancers [54]. Strategies such as complexation, microencapsulation, or inclusion into certain delivery systems may be employed to enhance the solubility, bioavailability, and skin penetration of these compounds [55][56][57][58]. Micronutrients are commonly delivered using enhancers such as gums, oral tablets, buccal sprays, creams, gels, and ointments [59,60].…”

Section: Introductionmentioning

confidence: 99%

Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review

Al-Smadi,

Ali,

Alavi

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

Vitamin D is one significant prohormone substance in human organ systems. It is a steroidal hormone produced in the skin upon exposure to UVB rays. This paper presents a systematic review of the utilization of topical vitamin D, specifically cholecalciferol, calcipotriol, and tacalcitol, in the treatment of vitiligo. It considers the role of vitamin D in stimulating the synthesis of melanin and melanogenesis, which can help with the process of repigmentation. The inclusion of calcipotriol or tacalcitol in Narrowband Ultraviolet Phototherapy (NB-UVB) has shown the potential to enhance therapeutic outcomes for vitiligo. However, their effectiveness in combination with Psoralens Long Wave Ultraviolet Radiation (PUVA) and Monochromatic Excimer Light (MEL) treatment for vitiligo is limited. In contrast, combining topical corticosteroids with vitamin D analogues has demonstrated superior efficacy in treating vitiligo compared to using vitamin D analogues alone, while also providing the added benefit of reducing corticosteroid-related adverse effects. In addition, treating stable vitiligo with topical cholecalciferol and microneedling has shown success. Future studies are needed to ascertain an efficient method of administering vitamin D topically as an anti-vitiligo agent.

show abstract

Section: Introductionmentioning

confidence: 99%

Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review

Al-Smadi,

Ali,

Alavi

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

Advances in Antileishmanial Chemotherapy

Shuhail,

Das,

Datta

et al. 2023

Challenges and Solutions Against Visceral Leishmaniasis

View full text Add to dashboard Cite

Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Alavi,

Koohi

et al. 2024

J. Pharm. Investig.

View full text Add to dashboard Cite

Background Nanometal-organic frameworks (nano-MOFs), which exhibit distinctive features, such as controlled release mechanisms, stimuli-responsive behaviors, and sustained drug release profiles, have emerged as promising candidates for next-generation drug delivery systems. Area covered This review outlines the impact of nano-MOFs in biomedical applications, emphasizing their potential for targeted drug delivery through active strategies and their biocompatibility considerations. Expert opinion The versatility and tunability of nano-MOFs pave the way for personalized medicine, allowing tailored formulations to meet individual patient needs. Despite their transformative potential, challenges remain in terms of stability, toxicity assessment, and standardization. As nano-MOFs progress from laboratory research to clinical trials, they present a paradigm shift in drug delivery, offering precision medicine solutions through theranostic platforms. The future holds promise for the use of nano-MOFs to revolutionize drug delivery, ushering in an era of personalized and effective therapeutic interventions.

show abstract

A topical gel nanoformulation of amphotericin B (AmB) for the treatment of cutaneous leishmaniasis (CL)

Cited by 13 publications

References 53 publications

Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review

Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review

Advances in Antileishmanial Chemotherapy

Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Contact Info

Product

Resources

About