A tomato homeobox gene (HD‐Zip) is involved in limiting the spread of programmed cell death

Mayda, Esther; Tornero, Pablo; Conejero, Vicente; Vera, Pablo

doi:10.1046/j.1365-313x.1999.00633.x

Cited by 50 publications

(44 citation statements)

References 39 publications

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“…The latter is characterized by an additional Leu zipper motif adjacent to the homeodomain that facilitates homodimerization and heterodimerization of the transcriptional regulators. Functional characterization of some members of the homeobox family supports a role for some of them as key regulators of hormone signaling (Himmelbach et al, 2002), adaptive responses to environmental cues (Steindler et al, 1999;Zhu et al, 2004), and pathogen-derived signaling processes (Mayda et al, 1999).…”

Section: Discussionmentioning

confidence: 96%

An Arabidopsis Homeodomain Transcription Factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, Mediates Resistance to Infection by Necrotrophic Pathogens

et al. 2005

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The mechanisms controlling plant resistance to necrotrophic fungal pathogens are poorly understood. We previously reported on Ep5C, a gene shown to be induced by the H 2 O 2 generated during a plant-pathogen interaction. To identify novel plant components operating in pathogen-induced signaling cascades, we initiated a large-scale screen using Arabidopsis thaliana plants carrying the b-glucuronidase reporter gene under control of the H 2 O 2 -responsive Ep5C promoter. Here, we report the identification and characterization of a mutant, ocp3 (for overexpressor of cationic peroxidase 3), in which the reporter construct is constitutively expressed. Healthy ocp3 plants show increased accumulation of H 2 O 2 and express constitutively the Glutathione S-transferase1 and Plant Defensine 1.2 marker genes, but not the salicylic acid (SA)-dependent pathogenesisrelated PR-1 gene. Strikingly, the ocp3 mutant shows enhanced resistance to the necrotrophic pathogens Botrytis cinerea and Plectosphaerella cucumerina. Conversely, resistance to virulent forms of the biotrophic oomycete Hyaloperonospora parasitica and the bacterial pathogen Pseudomonas syringae pv tomato DC3000 remains unaffected in ocp3 plants when compared with wild-type plants. Consistently with this, ocp3 plants are not affected in SA perception and express normal levels of PR genes after pathogen attack. To analyze signal transduction pathways where ocp3 operates, epistasis analyses between ocp3 and pad4, nahG, npr1, ein2, jin1, or coi1 were performed. These studies revealed that the resistance signaling to necrotrophic infection in ocp3 is fully dependent on appropriate perception of jasmonic acid through COI1 and does not require SA or ethylene perception through NPR1 or EIN2, respectively. The OCP3 gene encodes a homeodomain transcription factor that is constitutively expressed in healthy plants but repressed in response to infection by necrotrophic fungi. Together, these results suggest that OCP3 is an important factor for the COI1-dependent resistance of plants to infection by necrotrophic pathogens.

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Section: Discussionmentioning

confidence: 96%

An Arabidopsis Homeodomain Transcription Factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, Mediates Resistance to Infection by Necrotrophic Pathogens

et al. 2005

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“…SlHZ25 (H52) was involved in cellular protection by limiting spread of programmed cell death in plants, which showed a close relationship with ATHB5, -6, and -16 of class I in clade β2. 19,45) VA-HOX1 is one of tomato HD-Zip I protein in η clade protein whose expression increased in sepals after cold treatment, its regulation induced by cool temperatures was independent of ethylene. 46) LeHB-1 of tomato HDZip I gene in β2 clade is not only involved in the control of ripening but also plays a critical role in floral organogenesis.…”

Section: Phylogenetic Classification and Structural Analysis Of Slhz mentioning

confidence: 99%

A genome-wide survey of homeodomain-leucine zipper genes and analysis of cold-responsive HD-Zip I members’ expression in tomato

Zhang

Chen

Guan

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Homeodomain-leucine zipper (HD-Zip) proteins are a kind of transcriptional factors that play a vital role in plant growth and development. However, no detailed information of HD-Zip family in tomato has been reported till now. In this study, 51 HD-Zip genes (SlHZ01-51) in this family were identified and categorized into 4 classes by exon–intron and protein structure in tomato (Solanum lycopersicum) genome. The synthetical phylogenetic tree of tomato, Arabidopsis and rice HD-Zip genes were established for an insight into their evolutionary relationships and putative functions. The results showed that the contribution of segmental duplication was larger than that of tandem duplication for expansion and evolution of genes in this family of tomato. The expression profile results under abiotic stress suggested that all SlHZ I genes were responsive to cold stress. This study will provide a clue for the further investigation of functional identification and the role of tomato HD-Zip I subfamily in plant cold stress responses and developmental events.

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“…CfHNNI1 may function as a cytoplasmic bZIP transcription factor, either directly activating HR and defence signalling through the regulation of downstream plant gene expression, or activating the expression of an elicitor gene of plant origin thereby resulting in the accumulation of active plant elicitor, which then initiates downstream HR signalling. In this context it is noteworthy that H52, a tomato transcription factor containing a leucine-zipper domain, is involved in regulation of programmed cell death (Mayda et al 1999), inferring that the bZIP transcription factor may play a direct role in the regulation of HR and resistance. Additionally, we previously found that amino acids conserved in these domains of bZIP transcription factors are essential for the full function of CfHNNI1 (Cai 2004).…”

Section: Discussionmentioning

confidence: 99%

Cladosporium fulvum CfHNNI1 induces hypersensitive necrosis, defence gene expression and disease resistance in both host and nonhost plants

Cai

Zhou

et al. 2007

Plant Mol Biol

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Nonhost resistance as a durable and broadspectrum defence strategy is of great potential for agricultural applications. We have previously isolated a cDNA showing homology with genes encoding bZIP transcription factors from tomato leaf mould pathogen Cladosporium fulvum. Upon expression, the cDNA results in necrosis in C. fulvum host tomato and nonhost tobacco plants and is thus named CfHNNI1 (for C. fulvum host and nonhost plant necrosis inducer 1). In the present study we report the induction of necrosis in a variety of nonhost plant species belonging to three families by the transient in planta expression of CfHNNI1 using virus-based vectors. Additionally, transient expression of CfHNNI1 also induced expression of the HR marker gene LeHSR203 and greatly reduced the accumulation of recombinant Potato virus X. Stable CfHNNI1 transgenic tobacco plants were generated in which the expression of CfHNNI1 is under the control of the pathogeninducible hsr203J promoter. When infected with the oomycetes pathogen Phytophthora parasitica var. nicotianae, these transgenic plants manifested enhanced expression of CfHNNI1 and subsequent accumulation of CfHNNI1 protein, resulting in high expression of the HSR203J and PR genes, and strong resistance to the pathogen. The CfHNNI1 transgenic plants also exhibited induced resistance to Pseudomonas syringae pv. tabaci and Tobacco mosaic virus. Furthermore, CfHNNI1 was highly expressed and the protein was translocated into plant cells during the incompatible interactions between C. fulvum and host and nonhost plants. Our results demonstrate that CfHNNI1 is a potential general elicitor of hypersensitive response and nonhost resistance.

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A tomato homeobox gene (HD‐Zip) is involved in limiting the spread of programmed cell death

Cited by 50 publications

References 39 publications

An Arabidopsis Homeodomain Transcription Factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, Mediates Resistance to Infection by Necrotrophic Pathogens

An Arabidopsis Homeodomain Transcription Factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, Mediates Resistance to Infection by Necrotrophic Pathogens

A genome-wide survey of homeodomain-leucine zipper genes and analysis of cold-responsive HD-Zip I members’ expression in tomato

Cladosporium fulvum CfHNNI1 induces hypersensitive necrosis, defence gene expression and disease resistance in both host and nonhost plants

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