A Toggle Nanoswitch Alternately Controlling Two Catalytic Reactions

Abstract

Reversible switching between two states of the triangular nanoswitch [Cu(1)](+) was accomplished by alternate addition of 2-ferrocenyl-1,10-phenanthroline (2) and copper(I) ions. The two switching states regulate the binding and release of two distinct catalysts, piperidine and [Cu(2)](+), in a fully interference-free manner and allow alternating on/off switching of two orthogonal catalytic processes. In switching state I, piperidine is released from the nanoswitch and catalyzes a Knoevenagel addition between 4-nitrobenzaldehyde and diethyl malonate (ON-1 and OFF-2), while in state II the released [Cu(2)](+) catalyzes a click reaction between 4-nitrophenylacetylene and benzylazide (OFF-1 and ON-2). Upon addition of one equivalent of 2 to the (OFF-1 and ON-2)-state, both catalytically active processes are shut down (OFF-1 and OFF-2).

Direct Self‐Assembly of a 2D and 3D Star of David

“…[1] In particular, coordination-driven self-assembly has witnessed significant growth, with the construction of ab road array of metallosupramolecules of increasing complexity. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] TheS tar of David, ah exagram (or figure composed of two equilateral triangles) recognized as the symbol of Jewry,has been explored extensively across science, mathematics,e ngineering,t echnology,b usiness,h istory,a nd art. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] TheS tar of David, ah exagram (or figure composed of two equilateral triangles) recognized as the symbol of Jewry,has been explored extensively across science, mathematics,e ngineering,t echnology,b usiness,h istory,a nd art.…”

Dynamic Functional Molecular Systems: From Supramolecular Structures to Multi‐Component Machinery and to Molecular Cybernetics

“…Finally, the catalytic action during forward and backward walking of biped ligand 23c on track 38 was studied . For this purpose (Scheme ), the substrates 25 , 26 and catalyst 24 were added to ( 38 ) ⋅ ( 23 c ) (200 : 200 : 18 : 10).…”

“… Catalytic action of the supramolecular walker assembly . Adapted with permission from the ACS, copyright ACS 2018.…”

Dynamic Responsive Systems for Catalytic Function

“…Very recently, the same group reported an example of the regulation of two different reactions . The new system (Scheme ) can exist in three states, each of which consists of two metal centers, copper and zinc, either of which can be blocked by coordination of the inhibitory arm.…”