A TOF mass spectrometer with higher resolution and sensitivity via elimination of chromatic TOF aberrations of higher orders

Bimurzaev, S. B.

doi:10.1016/j.ijms.2014.11.007

Cited by 5 publications

(4 citation statements)

References 2 publications

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“…The scheme in figure 5 provides spatial second-order focusing (with respect to the parameter x = r 0 ) and fourth-order time-of-flight focusing (with respect to the parameter x = z 0 ); it is in absolute agreement with the results of [21]. The coincidence of the positions of the corresponding foci according to the results of calculations by the proposed method is observed at the value of the accelerating pulse V 0 = 1.08V, and the value of the focal length in this case is z f = d 11.04 , in contrast to the analytical value z f = d 8.06 presented in [21]. The presented graphical results in figure 5 demonstrate the actual coincidence of the spatial and time-of-flight foci at the distance z f = d 11.04 and at the time point t .…”

Section: Testing and Application Of The Methodssupporting

confidence: 64%

“…Whereas the problems of synthesizing systems with new corpuscular-optical properties are solved with great success by analytical methods, in particular, methods of paraxial optics using the means of the aberration theory to eliminate or reduce the most significant aberration coefficients. In work [21], a scheme of a time-of-flight axially-symmetric mass analyzer with a straight optical axis is synthesized, in which the spatial and time-of-flight foci are combined. However, the calculated parameters of the proposed mass analyzer can be considered only approximate due to the low accuracy of paraxial methods and the analytical approximation of the axial potential distribution.…”

Section: Testing and Application Of The Methodsmentioning

confidence: 99%

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Numerical search for time-of-flight focusing conditions and its application to the analysis of TOF mass analyzer schemes

Kambarova,

Saulebekov,

Trubitsyn

2024

Eng. Res. Express

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A method of searching for high-order time-of-flight focusing conditions based on data of numerical trajectory analysis of corpuscular-optical systems is presented. The method makes it possible to determine the maximum achievable order of focusing, the value of the independent variable (initial coordinate, initial angle, initial velocity or energy) relative to which the focusing is observed, as well as the spatial position of focus. The method has been tested on model problems. The corpuscular-optical properties of time-of-flight devices with known analytical solutions are investigated, and the uniqueness of their parameters in their class is shown.

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Section: Testing and Application Of The Methodssupporting

confidence: 64%

Section: Testing and Application Of The Methodsmentioning

confidence: 99%

Numerical search for time-of-flight focusing conditions and its application to the analysis of TOF mass analyzer schemes

Kambarova,

Saulebekov,

Trubitsyn

2024

Eng. Res. Express

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“…According to [9], U push = 1000 V, U acc ≈5U push , d push = 4 mm. The results of calculation of the dependence of the ratio of the widths / z z υ υ ∆ ∆ in the ion packet on d acc in the primary time focus, taking into account these data and α = 2.5, are presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Improving the resolution and sensitivity of an orthogonal time-of-flight mass spectrometer with orthogonal ion injection

Bimurzaev,

Aldiyarov,

Yerzhigitov

et al. 2023

EEJET

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The theoretical possibilities of increasing the resolution and sensitivity of a time-of-flight mass spectrometer with orthogonal ion injection are considered. The effects are achieved by using inhomogeneous electrostatic fields of special configurations both in the accelerating and focusing parts of the device – a cylindrical immersion objective and a transaxial mirror, respectively. It is shown that the use of an inhomogeneous cylindrical field of a special configuration as an ion accelerator opens up the possibility of a multiple reduction in the energy spread of ions in injected ion packets, associated with the so-called "turnaround time" and, therefore, a significant (two or more times) increase in the limiting resolution of the mass spectrometer. The use of a transaxial electrostatic mirror as a time-of-flight mass analyzer makes it possible to significantly increase the sensitivity of the mass-spectrometer due to the implementation of triple space-time-of-flight focusing of ion packets. Key features include reduced ion energy spread, increased maximum resolution, and improved sensitivity due to triple focusing in space and time of flight. This research lays the foundation for expanding the capabilities of time-of-flight mass spectrometry, providing a more efficient and powerful tool for a wide range of scientific and industrial applications. The effects are achieved by using inhomogeneous electrostatic fields of a special configuration in both the accelerating and focusing parts of the device – a cylindrical immersion lens and a transaxial mirror, respectively. Numerical calculations of the system – a four-electrode cylindrical immersion lens in combination with a three-electrode transaxial mirror – are presented, which confirm the conclusions of the theory

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“…The spectrometer resolution can particularly be improved by applying pulsed extraction fields . This design is still used, although several improvements have been suggested and tested, such as ion‐optical elements (ion mirrors), in which accelerating fields are created without applying meshes . Important conclusions were drawn by De Heer and Milani and by Chandezon et al, who required that the spread of flight times for ions generated within a given spatial range is minimized.…”

Section: Introductionmentioning

confidence: 99%

Time‐of‐flight mass spectrometers based on a wedge‐shaped electrostatic mirror with a two‐dimensional field

Spivak-Lavrov

Baisanov²,

Yakushev³

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale: For most of the last two decades, a considerable effort has been made towards improving time-of-flight mass spectrometry (TOF MS), which has become an irreplaceable instrumental platform for the purposes of performing analytical measurements in life sciences, such as molecular biology, proteomics, medicine, etc.This can primarily be attributed to the ability of TOF MS to rapidly detect and identify nearly any targeted chemical trace with both high precision and accuracy.However, multi-span TOF MS experiments are limited due to aberrations arising from multiple reflection; our proposed scheme will minimize these aberrations. Methods:The inhomogeneous accelerating field is generated without using meshes by changing the potentials on the electrodes of the mirror. The ions are extracted from the ion source by short impulse activation of the accelerating electric field.Since the ions are extracted from various points of the source, even ions with identical masses acquire different velocities during acceleration. Results:We have shown that the "rear" ions of the packet catch up with the "front" ions, and packets of ions with identical masses are compressed in the direction of their movement. It is concluded that, by placing the detector in a plane with the greatest compression of ion packets, an enhanced performance of a time-of-flight mass spectrometer is achieved. Conclusions:We have shown that effective spatial-temporal focusing allows a small mass spectrometer to achieve high resolution and sensitivity. We also propose and numerically evaluate a new platform for designing multi-stage and multireflective time-of-flight analyzers with wedge-shaped mirrors. We applied the simulation results to the modernization of old equipment and showed that by simply replacing the electrostatic mirror with an optimized one, a significant increase in the analyzing power can be achieved.

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A TOF mass spectrometer with higher resolution and sensitivity via elimination of chromatic TOF aberrations of higher orders

Cited by 5 publications

References 2 publications

Numerical search for time-of-flight focusing conditions and its application to the analysis of TOF mass analyzer schemes

Numerical search for time-of-flight focusing conditions and its application to the analysis of TOF mass analyzer schemes

Improving the resolution and sensitivity of an orthogonal time-of-flight mass spectrometer with orthogonal ion injection

Time‐of‐flight mass spectrometers based on a wedge‐shaped electrostatic mirror with a two‐dimensional field

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