A TNF-α blocking peptide that reduces NF-κB and MAPK activity for attenuating inflammation

Wang, Yue; Ye, Ruiwei; Fan, Liming; Zhao, Xin; Li, Linxue; Zheng, Hao; Qiu, Yan; He, Xiuli; Lu, Yiming

doi:10.1016/j.bmc.2023.117420

Cited by 5 publications

(2 citation statements)

References 59 publications

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“…Upon interaction with its receptors, TNF-α triggers a cascade of signaling pathways that ultimately culminate in the activation of nuclear factor-kappaB (NF-κB), a pivotal transcription factor involved in the regulation of genes associated with inflammatory processes ( Wang Y. et al, 2023 ). In order to investigate the potential relationship between the inhibitory effect of 4b on ICAM-1 and MCP-1 expression, as well as its impact on NF-κB transcriptional activity, the inhibitory potency of 4b on NF-κB transcription was determined.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Zhao,

Hou,

Yan

et al. 2024

Front. Chem.

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This study introduces newly discovered chrysin derivatives that show potential as candidate molecules for treating inflammatory bowel disease (IBD). Compound 4b, among the synthesized compounds, displayed significant inhibitory effects on monocyte adhesion to colon epithelium induced by TNF-α, with an IC50 value of 4.71 μM. Further mechanistic studies demonstrated that 4b inhibits the production of reactive oxygen species (ROS) and downregulates the expression of ICAM-1 and MCP-1, key molecules involved in monocyte-epithelial adhesion, as well as the transcriptional activity of NF-κB. In vivo experiments have shown that compound 4b exhibits a dose-dependent inhibition of 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats, thereby validating its effectiveness as a colitis inhibitor in animal models. These results indicate that 4b shows considerable promise as a therapeutic agent for managing IBD.

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Section: Resultsmentioning

confidence: 99%

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Zhao,

Hou,

Yan

et al. 2024

Front. Chem.

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“…Therefore, corroborating our results, it is evident that markers like NFκB, CREB, Tau, SP, and AChE and inflammatory mediators like TNF-α and IL-6 are inter-connected, especially in the conditions of neurodegenerative conditions like AD. Modulation of TNF-α and IL-6 levels is dependent on the NFκB activity [ 114 , 115 ]. The NFκB signaling also promotes Tau-mediated toxicity [ 116 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer’s Disease

Satarker,

Gurram,

Nassar

et al. 2023

Mol Neurobiol

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Alzheimer’s disease (AD), a neurodegenerative condition previously known to affect the older population, is also now seen in younger individuals. AD is often associated with cognitive decline and neuroinflammation elevation primarily due to amyloid β (Aβ) accumulation. Multiple pathological complications in AD call for therapies with a wide range of neuroprotection. Our study aims to evaluate the effect of N-acetyl-L-tryptophan (NAT) in ameliorating the cognitive decline and neuroinflammation induced by Aβ 1-42 oligomers and to determine the therapeutic concentration of NAT in the brain. We administered Aβ 1-42 oligomers in rats via intracerebroventricular (i.c.v.) injection to induce AD-like conditions. The NAT-treated animals lowered the cognitive decline in the Morris water maze characterized by shorter escape latency and increased path efficiency and platform entries. Interestingly, the hippocampus and frontal cortex showed downregulation of tumor necrosis factor, interleukin-6, and substance P levels. NAT treatment also reduced acetylcholinesterase activity and total and phosphorylated nuclear factor kappa B and Tau levels. Lastly, we observed upregulation of cAMP response element-binding protein 1 (CREB1) signaling. Surprisingly, our HPLC method was not sensitive enough to detect the therapeutic levels of NAT in the brain, possibly due to NAT concentrations being below the lowest limit of quantification of our validated method. To summarize, the administration of NAT significantly lowered cognitive decline, neuroinflammatory pathways, and Tau protein and triggered the upregulation of CREB1 signaling, suggesting its neuroprotective role in AD-like conditions.

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The mechanism exploration of different colored rice for immunomodulation based on UPLC-Q-TOF, network pharmacology, and cell experiments

Sha,

Ma,

et al. 2024

Food Research International

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A TNF-α blocking peptide that reduces NF-κB and MAPK activity for attenuating inflammation

Cited by 5 publications

References 59 publications

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer’s Disease

The mechanism exploration of different colored rice for immunomodulation based on UPLC-Q-TOF, network pharmacology, and cell experiments

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