A tissue engineering approach based on the use of bioceramics for bone repair

Salinas, Antonio J.; Esbrit, Pedro; Vallet‐Regí, María

doi:10.1039/c2bm00071g

Cited by 138 publications

(106 citation statements)

References 106 publications

(119 reference statements)

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“…This type of Si-enriched ceramic has a narrow mesopore size distribution (in the nanometre range) but a large surface area that governs the interaction with the host bone tissue. However, these materials were non-degradable and induced the formation of a thick fibrous cup around the implant [3,27,29]. This prompted us to evaluate whether loading PTHrP (107-111) into HA Glu scaffolds would provide a more appropriate biomaterial as an implant for improving new bone formation.…”

Section: Discussionmentioning

confidence: 99%

“…Bone healing involves a variety of cellular and molecular events that lead to new bone formation [2,3]. This process recapitulates most of the features of normal bone development during embryogenesis, but it is highly influenced by factors such as mechanical loading and the relative abundance of osteoprogenitors (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Current interest is focused on bioactive and biodegradable bioceramics as scaffolds exhibiting suitable osteointegration and osteoconductive features in bone tissue engineering applica-tions [7,8]. In this line, hydroxyapatite (HA) and other calcium phosphates are widely used as degradable scaffolds with interconnected porosity, including macropores in the 1-500 lm range allowing cellular internalization [3]. Recently, three-dimensional HA foams with a high degree of porosity were prepared by sol-gel routes, and coated with gelatin-glutaraldehyde biopolymers to give them flexibility and easy manipulation in orthopaedic applications [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin–glutaraldehyde biopolymer-coated hydroxyapatite

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin–glutaraldehyde biopolymer-coated hydroxyapatite

et al. 2014

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“…Osteoconductivity is used to define the ability of material in providing a structure to which cells can adhere, proliferate, and further propagate for bone tissue formation. Osteoinductivity defines the potential of materials for triggering osteogenic differentiation (Blokhuis and Arts 2011;Salinas et al 2013). In this study, calcium phosphate particles were evaluated for their biocompatibility and bioactivity properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

et al. 2015

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The present study evaluates the synthesis of biocompatible osteoconductive and osteoinductive nano calcium phosphate (CaP) particles by industrially applied, aerosol-derived flame spray pyrolysis method for biomedical field. Calcium phosphate nanoparticles were produced in a range of calciumto-phosphorus ratio, (1.20-2.19) in order to analyze the morphology and crystallinity changes, and to test the bioactivity of particles. The characterization results confirmed that nanometer-sized, spherical calcium phosphate particles were produced. The average primary particle size was determined as 23 nm by counting more than 500 particles in TEM pictures. XRD patterns, HRTEM, SAED, and SEM analyses revealed the amorphous nature of the asprepared nano calcium phosphate particles at low Ca/P ratios. Increases in the specific surface area and crystallinity were observed with the increasing Ca/P ratio. TGA-DTA analysis showed that the thermally stable crystal phases formed after 700°C. Cell culture studies were conducted with urine-derived stem cells that possess the characteristics of mesenchymal stem cells. Synthesized amorphous nanoparticles did not have cytotoxic effect at 5-50 lg/ml concentration range. Cells treated with the as-prepared nanoparticles had higher alkaline phosphatase (ALP) enzyme activity than control cells, indicating osteogenic differentiation of cells. A slight decrease in ALP activity of cells treated with two highest Ca:P ratios at 50 lg/ml concentration was observed at day 7. The findings suggest that calcium phosphate nanoparticles Guest Editors: Mustafa Culha, Rawil F. Fakhrullin, Ratnesh Lal This article is part of the topical collection on Nanobiotechnology Electronic supplementary material The online version of this article

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“…An important requirement is that these scaffolds exhibit an interconnected and hierarchical porosity, that is to say, with several orders of magnitude including giant pores (channels) and macropores that allow internal angiogenesis and the interaction with cells. Hormone related Peptide (PTHrP) [7].…”

Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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Highligths MBGs containing small amounts of Ga, Ce or Zn exhibit high in vitro bioactivity  The bioactive response is preserved after obtaining 3D scaffolds  These scaffolds are optimum candidates for bone tissue engineering applications  MBG scaffold with 4% ZnO exhibit bactericide action against S. Aureus  The effects of the extra ions is sometimes complex and needs to be investigated 2 Abstract 3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pores in a hierarchy of sizes. The ordered mesopores network (around 4 nm in diameter), is optimal for the adsorption and release of bone inductor biomolecules, and the arrangement of macropores over 100 m facilitates the bone cell ingrowths and angiogenesis. Nevertheless MBGs composition can be varied almost infinitely at the atomic scale by including in the glass network oxides of inorganic elements with a therapeutic action. In this article the synthesis and characterization of MBG scaffolds based on the 80%SiO2-15%CaO-5%P2O5 (in mol-%) glass with substitutions up to 3.5% of Ga2O3 or Ce2O3 or 7.0% of ZnO is revisited. The substituent inclusion and the RP processing slightly decrease the surface area, the pore volume and the mesoporous order as well as their bioactive response in solutions mimicking blood plasma. However, these values still remain useful for bone TE applications. Results exhibiting the bactericide action of MBG scaffolds containing ZnO are also presented. KeywordsMesoporous bioactive glass scaffolds; Ga, Ce and Zn as therapeutical ions; bactericide capability; bone tissue engineering 3

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A tissue engineering approach based on the use of bioceramics for bone repair

Cited by 138 publications

References 106 publications

Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin–glutaraldehyde biopolymer-coated hydroxyapatite

Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin–glutaraldehyde biopolymer-coated hydroxyapatite

Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis, and their effect on osteogenic differentiation of stem cells

Glasses in bone regeneration: A multiscale issue

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