A Time-Dependent History of Mood Disorders in a Murine Model of Neuropathic Pain

Yalçın, İpek; Bohren, Yohann; Waltisperger, Elisabeth; Sage-Ciocca, Dominique; Yin, Jie; Freund-Mercier, Marie José; Barrot, Michel

doi:10.1016/j.biopsych.2011.07.017

Cited by 192 publications

(194 citation statements)

References 55 publications

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“…Although the neurobiological mechanisms underlying the effects of MD on nociceptive responding in adulthood remain unknown, it has been shown that MD induces a range of sex-dependent developmental and psychoneuroimmunendocrine alterations 54 . It has been proposed that Alterations in affective responding such as anxiety-and depressive-like behaviours have been shown to be induced in a number of models of peripheral nerve injury 45,47,51,57 , although in the present study SNL failed to modulate affective behaviour. The short period following surgery over which these behaviours were examined (Day16), may account for the lack of effects as previous studies have indicated that alterations in affective behaviour only manifest after at least a month post-surgery 45,51,57 .…”

Section: Discussioncontrasting

confidence: 73%

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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Maternal deprivation is associated with sex dependant alterations in nociceptive behaviour and neuroinflammatory mediators in the rat following peripheral nerve injury. AbstractEarly-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and following peripheral nerve injury (L5-L6 spinal nerve ligation (SNL)). As neuroimmune signalling plays an important role in pain and affective disorders, associated alterations in glial and cytokine expression were assessed in key brain regions associated with emotional and nociceptive responding, the hippocampus and prefrontal cortex (PFC). MD female, but not male, rats exhibited thermal hypoalgesia and mechanical allodynia when compared to control (non-MD) counterparts. SNL resulted in mechanical and cold allodynia in MD and control rats of both sexes. However, MD females exhibited enhanced SNL-induced allodynic responding when compared to non-MD counterparts. IL-6 expression was reduced in the PFC of MD-SNL males when compared with non-SNL counterparts. GFAP and IL-1β expression in the hippocampus of MD-SNL males was increased compared with non-MD controls. MD-SNL females exhibited reduced TNFα in the PFC with a concomitant increase in IL-6 and TNFα expression in the hippocampus, compared with either MD or SNL alone. In conclusion, MD female, but not male, rats exhibit enhanced nociceptive responding following peripheral nerve injury, effects which may relate to the distinct neuroinflammatory profile observed in female versus male rats.Perspective: This study demonstrates that females rats exposed to early-life stress exhibit enhanced neuropathic pain responding, effects associated with alterations in neuroinflammatory mediators. Increased understanding of the interactions between early-life stress, gender and pain may lead to the identification o novel therapeutic targets for the treatment of chronic pain disorders.

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Section: Discussioncontrasting

confidence: 73%

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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“…We previously found that 2 weeks of neuropathic pain and chronic mild stress selectively increased the aversion to painful stimuli, without affecting classic depressive-like behaviours measured through the forced swimming and anhedonia test [10]. Thus, these and previous data corroborate that it takes approximately 4 weeks for rats to develop affective disorders (anxiety and depression) in association with neuropathic pain [2,19,37,43]. Nevertheless, further studies will be necessary to explore the effect of stress on the pain dimensions and secondary affective disorders over longer periods.…”

Section: Discussionsupporting

confidence: 73%

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Bravo

Alba-Delgado

Torres-Sánchez

et al. 2013

Pain

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a b s t r a c tStressful experiences seem to negatively influence pain perception through as yet unknown mechanisms. As the noradrenergic locus coeruleus (LC) nucleus coordinates many components of the stress response, as well as nociceptive transmission, we evaluated whether the sensory and affective dimension of chronic neuropathic pain worsens in situations of stress due to adaptive changes of LC neurons. Accordingly, male rats were socially isolated for 5 weeks, and in the last 2 weeks, neuropathic pain was induced by chronic constriction injury. In this situation of stress, chronic pain selectively heightened the animal's aversion to painful experiences (affective pain), as measured in the place escape/avoidance test, although no changes were observed in the sensory dimension of pain. In addition, electrophysiological recordings of LC neurons showed a low tonic but exacerbated nociceptive-evoked activity when the injured paw was stimulated. These changes were accompanied by an increase in tyrosine hydroxylase and gephyrin expression in the LC. Furthermore, intra-LC administration of bicuculline, a c-aminobutyric acid-A receptor antagonist, attenuated the negative affective effects of pain. These data show that changes in the LC are greater than those expected from the simple summation of each independent factor (pain and stress), revealing mechanisms through which stressors may exacerbate pain perception without affecting the sensorial dimension. Ó

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“…administration of IL-6 or IL-1β elicited hyperalgesia (50), as well as fever, anorexia, and reduction of social exploratory behavior (51,52). Three recent studies including ours have shown that peripheral nerve injury induced depressive behavior in rats (53)(54)(55), which is associated with an increased IL-1β expression in the frontal cortex (54). The present data demonstrate a direct link between cytokine signaling and IDO expression in the hippocampus.…”

Section: Figuresupporting

confidence: 66%

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

Kim¹,

Chen²,

Lim³

et al. 2012

J. Clin. Invest.

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A Time-Dependent History of Mood Disorders in a Murine Model of Neuropathic Pain

Cited by 192 publications

References 55 publications

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression

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