A TIGER Among Endoscopic Indices in Inflammatory Bowel Disease

Hanžel, Jurij; Jairath, Vipul

doi:10.1093/ecco-jcc/jjab235

Cited by 2 publications

(2 citation statements)

References 8 publications

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“… 12 , 26 A new scoring system named Toronto inflammatory bowel disease (IBD) global endoscopic reporting score has been introduced lately, which took into account all visualized colorectal segments. 27 , 28 This was beneficial to evaluate endoscopic full disease burden for IBD patients, but further studies were needed to validate the new scoring system, especially on the contribution of stenosis to the index. 28 It seemed that the modified DUBLIN score was practical for physicians due to the easy calculation and the association with disease severity and prognosis, but it was not appropriate to make therapeutic decision relying on a single score alone.…”

Section: Discussionmentioning

confidence: 99%

“… 27 , 28 This was beneficial to evaluate endoscopic full disease burden for IBD patients, but further studies were needed to validate the new scoring system, especially on the contribution of stenosis to the index. 28 It seemed that the modified DUBLIN score was practical for physicians due to the easy calculation and the association with disease severity and prognosis, but it was not appropriate to make therapeutic decision relying on a single score alone. We admitted that comprehensive consideration was needed when the physicians made treatment schedule.…”

Section: Discussionmentioning

confidence: 99%

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Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure

Liu

Ouyang

et al. 2022

Therap Adv Gastroenterol

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Background: Grading of endoscopic lesions is important for determining the severity of ulcerative colitis and developing treatment strategies, but the commonly used methods are not sufficient. Objectives: This study aimed to investigate whether new endoscopic scoring systems incorporating lesions and disease extent are associated with clinical disease severity and maintainable remission. Design: This was a retrospective study. In all, 110 patients with ulcerative colitis were included and 87 completed 12-month follow-up. Methods: Colonoscopy was performed within 1 week before blood samples were taken. Degree of ulcerative colitis burden of luminal inflammation (DUBLIN) scores were calculated as the product of Mayo endoscopic score (MES) by disease extent and ulcerative colitis endoscopic index of severity was used to replace MES when calculating modified DUBLIN scores. Results: DUBLIN and modified DUBLIN scores were increased in the moderate and severe groups significantly ( p < 0.05). Both of increased scores contributed to the detection of serious diseases, and the clinical cutoff values of DUBLIN and modified DUBLIN were 3[area under the curve (AUC) = 0.809, p = 0.001) and 7(AUC = 0.815, p = 0.001), respectively. They were with high sensitivity, but the specificity of DUBLIN was lower. Both scores were correlated to partial Mayo scores, C-reactive protein and erythrocyte sedimentation rate positively, and they were correlated to the albumin negatively ( p < 0.05). Higher modified DUBLIN scores (>7) were associated with an increased risk of treatment failure (hazard ratio = 4.96, 95% confidence interval: 1.17–21.00, p = 0.03), but there were no association between DUBLIN scores and long-term remission ( p > 0.05). Conclusion: Increased DUBLIN and modified DUBLIN scores were conducive to screening serious disease, but only modified DUBLIN scores had the potential to assist in making an upgraded therapeutic schedule.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure

Liu

Ouyang

et al. 2022

Therap Adv Gastroenterol

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Development and validation of a deep learning-based approach to predict the Mayo endoscopic score of ulcerative colitis

Ruan

et al. 2023

Therap Adv Gastroenterol

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Background: The ulcerative colitis (UC) Mayo endoscopy score is a useful tool for evaluating the severity of UC in patients in clinical practice. Objectives: We aimed to develop and validate a deep learning-based approach to automatically predict the Mayo endoscopic score using UC endoscopic images. Design: A multicenter, diagnostic retrospective study. Methods: We collected 15120 colonoscopy images of 768 UC patients from two hospitals in China and developed a deep model based on a vision transformer named the UC-former. The performance of the UC-former was compared with that of six endoscopists on the internal test set. Furthermore, multicenter validation from three hospitals was also carried out to evaluate UC-former’s generalization performance. Results: On the internal test set, the areas under the curve of Mayo 0, Mayo 1, Mayo 2, and Mayo 3 achieved by the UC-former were 0.998, 0.984, 0.973, and 0.990, respectively. The accuracy (ACC) achieved by the UC-former was 90.8%, which is higher than that achieved by the best senior endoscopist. For three multicenter external validations, the ACC was 82.4%, 85.0%, and 83.6%, respectively. Conclusions: The developed UC-former could achieve high ACC, fidelity, and stability to evaluate the severity of UC, which may provide potential application in clinical practice. Registration: This clinical trial was registered at the ClinicalTrials.gov (trial registration number: NCT05336773)

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A TIGER Among Endoscopic Indices in Inflammatory Bowel Disease

Cited by 2 publications

References 8 publications

Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure

Increased modified DUBLIN scores are associated with serious ulcerative colitis and treatment failure

Development and validation of a deep learning-based approach to predict the Mayo endoscopic score of ulcerative colitis

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