A threshold LC–MS/MS method for 92 analytes in oral fluid collected with the Quantisal® device

Simultaneous quantification of 19 nonsteroidal anti‐inflammatory drugs in oral fluid by liquid chromatography‐high resolution mass spectrometry: Application on ultratrail runner's oral fluid

“…Quantisal® is also known to exhibit higher extraction recovery and good reproducibility for many drugs of abuse and drugs like antipsychotics 36–38 . However, it has been reported that compounds like polyglycols present in the stabilizing buffer can hamper the MS detection 39 . Therefore, we compared Quantisal® buffer and a homemade mix containing ACN/H 2 O (50/50 v/v) + 2% acetic acid.…”

“…[36][37][38] However, it has been reported that compounds like polyglycols present in the stabilizing buffer can hamper the MS detection. 39 Therefore, we compared Quantisal ® buffer and a homemade mix containing ACN/H 2 O (50/50 v/v) + 2% acetic acid.…”

Detection of Flunitrazepam in Biological Fluids and Beverages:A Review

“…In specific experiments it was concluded that the loss of benzodiazepines, especially FLU and clonazepam, during natural storage is mainly due to irreversible adsorption of the substances on the collection device, and that pre‐addition of methanol to the collection device can significantly improve this state and achieve maximum stability. In 2020, also employing Quantisal™ collection OF, Desharnais and coworkers established a qualitative LC‐MS/MS decision point analysis method with high throughput and greater stability to monitor and validate the presence of benzodiazepines and metabolites [63] . This method was mainly optimized for the precipitation solvent used (acetone: acetonitrile 30 : 70 V: V), which dramatically improved the stability of FLU and 7AF.…”

“…In 2020, also employing Quantisal™ collection OF, Desharnais and coworkers established a qualitative LC-MS/MS decision point analysis method with high throughput and greater stability to monitor and validate the presence of benzodiazepines and metabolites. [63] This method was mainly optimized for the precipitation solvent used (acetone: acetonitrile 30 : 70 V: V), which dramatically improved the stability of FLU and 7AF.…”

Polydopamine coated hypodermic needles as a microextraction device for the determination of tricyclic antidepressants in oral fluid by direct infusion MS/MS

“…However, OF analysis faces the same challenges observed for conventional biosamples, namely: the low concentration of the analytes and the high presence of interferents. 15 The extraction of TCAs from OF by solid-phase extraction 16 and liquid–liquid extraction 17 has been reported as suitable approaches to overcome both issues.…”