A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate

Krishnaiah, Y. S. R.; Karthikeyan, Ramadoss; Satyanarayana, V.

doi:10.1016/s0378-5173(02)00273-9

Cited by 59 publications

(33 citation statements)

References 18 publications

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“…Most of these drugs, if not formulated properly, may readily release the drug at a faster rate and are likely to produce toxic concentrations when administered orally. 12 Natural gums are among the most popular hydrophilic polymers because of their cost-effectiveness and regulatory acceptance. Guar gum is a natural nonionic polysaccharide derived from the seeds of Cyamopsis tetragonolobus (Family Leguminosae).…”

Section: Introductionmentioning

confidence: 99%

Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

2006

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The objective of this work was to develop matrix sustainedrelease tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as costeffective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/carboxymethyl cellulose [CMC] with respect to in vitro drug release rate) and hydration rate of the polymers. Matrix tablets of tramadol (dose 100 mg) were produced by direct compression method. Different ratios of 100:0, 80:20, 60:40, 20:80, 0:100 of G gum (or X):HPMC, X gum:G gum, and triple mixture of these polymers (G gum, X gum, HPMC) were applied. After evaluation of physical characteristics of tablets, the dissolution test was performed in the phosphate buffer media (pH 7.4) up to 8 hours. Tablets with only X had the highest mean dissolution time (MDT), the least dissolution efficiency (DE 8 %), and released the drug following a zero-order model via swelling, diffusion, and erosion mechanisms. Guar gum alone could not efficiently control the drug release, while X and all combinations of natural gums with HPMC could retard tramadol HCl release. However, according to the similarity factor ( f 2 ), pure HPMC and H 8 G 2 were the most similar formulations to Topalgic-LP as the reference standard.

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Section: Introductionmentioning

confidence: 99%

Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

2006

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“…The nature of the polymer therefore plays an important role in this swelling process. The presence of water in the polymer causes a stress, resulting in hydration of the polymer, which swells to yield a gelatinous viscous layer [15,16].…”

Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Zheng¹,

Wang²,

Du³

2015

Trop. J. Pharm Res

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“…A natureza do polímero é determinante no processo de intumescimento em comprimidos matriciais [19,20] . Quando se aumenta a concentração de polissacarídeo na formulação favorece a hidratação do sistema matricial, e consequentemente, a formação de uma camada viscosa gelatinosa, o que influencia diretamente no controle de liberação do fármaco [20] . Na Figura 2, estão representados os perfis de liberação das formulações contendo GG e/ou HPMC.…”

Section: Grau De Intumescimento (Gi) E Perfil De Liberação Do Fármacounclassified

“…Diante disso, no presente estudo foi utilizada a HPMC em associação à GG em diferentes razões. Após adição de HPMC na matriz, os demais lotes A Goma guar constitui um material promissor frente à liberação controlada de fármacos em sistemas matriciais [19][20][21] . No entanto, este polissacarídeo utilizado sozinho não foi capaz de controlar a taxa de teofilina liberada, por isso foi associado a um polímero hidrofílico (HPMC), amplamente utilizado em comprimidos de liberação controlada [22][23][24] .…”

Section: Grau De Intumescimento (Gi) E Perfil De Liberação Do Fármacounclassified

Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina

et al. 2015

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ResumoO objetivo desse estudo foi formular e avaliar comprimidos de liberação controlada. Comprimidos de liberação controlada de teofilina foram preparadas pelo método de compressão direta usando dois polímeros como, o HPMC K 100M (polímero hidrofílico) e a Goma Guar (Polímero natural), isolado ou em mistura (GG:HPMC 3:1) e GG:HPMC 1:3). Os comprimidos foram caracterizados através do peso médio, diâmetro, altura, dureza, friabilidade. Todos os resultados estiveram em conformidade com os limites aceitáveis. O ensaio de intumescimento foi realizado em água destilada durante 4 horas, sendo determinado pela diferença de peso do comprimido seco e intumescido. O ensaio de dissolução foi realizado em água destilada (900 mL, 37 ± 0,5ºC, 50 rpm, aparato II) durante 8 horas. Os resultados demonstraram que a Goma guar isolada não possui capacidade de retardar a liberação da teofilina por 8 horas. Comprimidos matriciais contendo GG:HPMC (3:1) apresentaram um melhor controle de liberação da teofilina. Palavras-chave: Goma Guar, teofilina, comprimidos, liberação controlada. AbstractGuar gum (GG) has been widely used in drug delivery systems due to its low cost and nontoxicity. Theophylline controlled release tablets were prepared by directly compressed method using two polymers such as HPMC K 100M (hydrophilic polymer) and Guar Gum (natural polymer), isolated or in mixture (GG:HPMC 3:1 and GG:HPMC 1:3). The formulated tablets were evaluated for: weight variation, diameter, height, hardness and friability. All the parameters were within the acceptable limits. The swelling test was performed in distilled water for 4 hours, it was determined by the difference in weight of the dry and swollen tablet. The dissolution test was performed in distilled water (900 mL, 37 ± 0.5ºC, 50 rpm, apparatus II) for 8 hours. The results showed that guar gum alone could not control the theophylline release effectively for 8 hours. Matrix tablet prepared from GG: HPMC (3:1) is a better formulation for the sustained released matrix tablets of theophylline.

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A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate

Cited by 59 publications

References 18 publications

Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride

Preparation and Characterization of Sustained Release Matrix Tablets of Tizanidine Hydrochloride for Spinal Injuries

Avaliação da Goma Guar no desenvolvimento de comprimidos matriciais de liberação controlada de teofilina

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