A three-dimensional ultrasonographic quantitative analysis of non-ulcerated carotid plaque morphology in symptomatic and asymptomatic carotid stenosis

Heliopoulos, John; Vadikolias, Κonstantinos; Mitsias, Panayiotis; Artemis, Dimitrios; Trιpsianis, Grigorios; Piperidou, Charitomeni; Artemis, N.

doi:10.1016/j.atherosclerosis.2007.11.036

Cited by 26 publications

(24 citation statements)

References 41 publications

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“…The limitation of 2D gray-scale evaluation of plaque is that single or even multiple images cannot represent the entire plaque volume. Heliopoulos et al [18] tried to measure the echogenicity of the entire volume of plaque with 3D ultrasonography. In 110 symptomatic and 104 asymptomatic patients with carotid plaque disease, they assessed the mean gray value of the whole plaque and found a higher incidence of low echoic plaque in symptomatic patients than in asymptomatic patients, suggesting a higher risk of cerebral ischemia from the low echoic plaque.…”

Section: Plaque Morphology and Plaque Volumementioning

confidence: 99%

General principles of carotid Doppler ultrasonography

Lee

2013

Ultrasonography

100

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Carotid Doppler ultrasonography is a popular tool for evaluating atherosclerosis of the carotid artery. Its two-dimensional gray scale can be used for measuring the intima-media thickness, which is very good biomarker for atherosclerosis and can aid in plaque characterization. The plaque morphology is related to the risk of stroke. The ulceration of plaque is also known as one of the strong predictors of future embolic event risk. Color Doppler ultrasonography and pulse Doppler ultrasonography have been used for detecting carotid artery stenosis. Doppler ultrasonography has unique physical properties. The operator should be familiar with the physics and other parameters of Doppler ultrasonography to perform optimal Doppler ultrasonography studies.

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Section: Plaque Morphology and Plaque Volumementioning

confidence: 99%

General principles of carotid Doppler ultrasonography

Lee

2013

Ultrasonography

100

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“…3 Novel evidence assumes carotid plaque composition analysis as a promising strategy for stroke risk stratification. 4 Surrogate markers suggesting "vulnerability" to plaque rupture could, therefore, aid the selection of individuals for whom aggressive treatment would reduce the likelihood of disabling stroke or death. Clinical trials have demonstrated the strong relationship of carotid plaque echolucency with the histologic content of vulnerable carotid plaque and the subsequent risk of ipsilateral ischemic stroke.…”

mentioning

confidence: 99%

Aggressive lipid-lowering is more effective than moderate lipid-lowering treatment in carotid plaque stabilization

Kadoglou

Sailer

Moumtzouoglou

et al. 2010

Journal of Vascular Surgery

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“…New ultrasound techniques promise to provide additional insight into the vulnerability of the carotid plaque [5]. Three-dimensional ultrasound quantitative analysis of the carotid plaque is a new technique that may help identify vulnerable plaques [5].…”

Section: Ultrasound In the Evaluation Of The Carotid Plaquementioning

confidence: 99%

“…Three-dimensional ultrasound quantitative analysis of the carotid plaque is a new technique that may help identify vulnerable plaques [5]. Images are acquired obtaining routine 2-D ultrasound imaging, but conversion into 3-D ultrasound helps overcome the inability of 2-D ultrasound to evaluate the composition of the entire plaque.…”

Section: Ultrasound In the Evaluation Of The Carotid Plaquementioning

confidence: 99%

Evaluating the Carotid Plaque: Going beyond Stenosis

Chalela¹

2009

Cerebrovasc Dis

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Background: Carotid disease is an important cause of ischemic stroke. Traditionally, therapeutic efforts in carotid disease have been aimed at identifying carotid stenosis in symptomatic patients and treating high-grade stenosis. New research suggests that identifying the vulnerable plaque in symptomatic or asymptomatic patients may be a more rational approach for the prevention of ischemic events. Methods: The author reviews some key references on identification of the vulnerable carotid plaque using different imaging modalities and using biochemical markers. The potential applications of such tools are discussed. Results: Carotid ultrasound, computed tomography, and magnetic resonance angiography can help identify plaque features associated with the so-called vulnerable plaque. Carotid ultrasound is the most widely studied modality and the easiest to perform and interpret. Concomitant measurement of serum biochemical markers associated with atherosclerosis, inflammation, and thrombosis may help identify the vulnerable carotid plaque. Conclusions: A multimodal approach to studying the carotid plaque appears to be a promising tool in identifying vulnerable carotid plaques. The current literature suggests that in addition to the degree of stenosis other imaging and biochemical findings have important clinical significance.

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A three-dimensional ultrasonographic quantitative analysis of non-ulcerated carotid plaque morphology in symptomatic and asymptomatic carotid stenosis

Cited by 26 publications

References 41 publications

General principles of carotid Doppler ultrasonography

General principles of carotid Doppler ultrasonography

Aggressive lipid-lowering is more effective than moderate lipid-lowering treatment in carotid plaque stabilization

Evaluating the Carotid Plaque: Going beyond Stenosis

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