A three‐dimensional particle simulation of the formation and collapse of a primary thrombus

Kamada, Hiroki; Tsubota, Ken Ichi; Nakamura, Masanori; Wada, Shigeo; Ishikawa, Takuji; Yamaguchi, Takami

doi:10.1002/cnm.1367

Cited by 47 publications

(49 citation statements)

References 27 publications

(39 reference statements)

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“…Just in recent years integrated thrombogenesis and multiscale models have been developed, which aim to give a more complete description of the blood clotting process. Continuum approaches are used in [Anand et al, 2005], [Narracott et al, 2005], [Bernsdorf et al, 2008], [Bódnar and Sequeira, 2008], [Leiderman and Fogelson, 2011], while discrete approaches are used in [Pivkin et al, 2006], [Xu et al, 2008], [Xu et al, 2009], [Kamada et al, 2010]. A microscale discrete model and a macroscale continuum models are presented in [Fogelson and Guy, 2008].…”

Section: State Of the Artmentioning

confidence: 99%

A continuum model for platelet plug formation, growth and deformation

Storti

Vosse

2014

Numer Methods Biomed Eng

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SUMMARYA numerical framework for modelling platelet plug dynamics is presented in this work. It consists of an extension of a biochemical and plug growth model with a solid mechanics model for the plug coupled with a fluid–structure interaction model for the blood flow–plug system. The platelet plug is treated as a neo‐Hookean elastic solid, of which the implementation is based on an updated Lagrangian approach. The framework is applied to different haemodynamic configurations coupled with different shear moduli of the plug. Results about plug growth, shape and size, as well as the stress distribution, are shown. Based on the simulations performed, we conclude that the deformability of the platelet plug is essential for its growth. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: State Of the Artmentioning

confidence: 99%

A continuum model for platelet plug formation, growth and deformation

Storti

Vosse

2014

Numer Methods Biomed Eng

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“…The numerical approaches using Computational Fluid Dynamics (CFD) techniques in modelling biomicrofluidic devices generally fall into two categories: i) explicitly modelling of biocells using EulerianLagrangian model for investigating their detailed individual behaviour in local mechanisms by means of the immersed finite element/boundary method (IFEM/IBM) [18,19] or the moving particle semi-implicit method (MPS) [20,21], ii) modelling of the bulk bioflow field in the whole device for predicting the biofluid behaviour based on relevant effects or laws [17,22], such as the Fahraeus effect [23] and Fahraeus-Lindqvist [24] effect, the Zweifach-Fung bifurcation law [25], the cell-free layer phenomenon and the bending channel centrifugal effect. The bulk bioflow can be modelled as a single phase liquid, i.e.…”

Section: I)mentioning

confidence: 99%

Progress towards the design and numerical analysis of a 3D microchannel biochip separator

Xue¹,

Marson²,

Patel³

et al. 2011

Numer Methods Biomed Eng

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This paper reports the design and numerical analysis of a three‐dimensional biochip plasma blood separator using computational fluid dynamics techniques. Based on the initial configuration of a two‐dimensional (2D) separator, five three‐dimensional (3D) microchannel biochip designs are categorically developed through axial and plenary symmetrical expansions. These include the geometric variations of three types of the branch side channels (circular, rectangular, disc) and two types of the main channel (solid and concentric). Ignoring the initial transient behaviour and assuming that steady‐state flow has been established, the behaviour of the blood fluid in the devices is algebraically analysed and numerically modelled. The roles of the relevant microchannel mechanisms, i.e. bifurcation, constriction and bending channel, on promoting the separation process are analysed based on modelling results. The differences among the different 3D implementations are compared and discussed. The advantages of 3D over 2D separator in increasing separation volume and effectively depleting cell‐free layer fluid from the whole cross section circumference are addressed and illustrated. Copyright © 2011 John Wiley & Sons, Ltd.

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“…Kamada et al proposed a series of multiscale models for platelet thrombus formation [9][10][11]. The flow of plasma and platelets is modeled by the moving particle semi-implicit (MPS) method in macroscale and the motion of the adhered and aggregated platelets is modeled by mechanical spring forces in microscale.…”

Section: Introductionmentioning

confidence: 99%

A 3D simulation of the formation of primary platelet thrombi based on a hybrid computational model

Ma¹,

Gwun²

2017

Turk J Elec Eng & Comp Sci

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Abstract:Recently, the study of thrombosis simulation based on computational models has been one of the most popular research areas. In this paper, a 3D simulation method based on a hybrid model is proposed for platelet thrombus formation. The flow of platelets is modeled in a macroscale submodel using Navier-Stokes equations and the physiological processes such as adhesion and aggregation of platelets are modeled in a microscale submodel. In the adhesion and aggregation phases, the attraction of platelets due to blood coagulation factors (von Willebrand factor) is modeled using the external force, and the conversion from unstable aggregation to stable aggregation is modeled using the increase in local viscosity. The proposed model is implemented and is applied to the 3D simulation of platelet thrombus formation. The flow of platelets and the transformation from normal platelet to thrombus are well shown by the 3D view of the simulation. The velocity field and viscosity field are also rendered to observe their changes in the process of thrombus formation. In the simulation, as the increase in blood velocity, the primary thrombus grows rapidly before a velocity threshold, and then the growth rate decreases. It concurs with the experimental results in vivo.

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A three‐dimensional particle simulation of the formation and collapse of a primary thrombus

Cited by 47 publications

References 27 publications

A continuum model for platelet plug formation, growth and deformation

A continuum model for platelet plug formation, growth and deformation

Progress towards the design and numerical analysis of a 3D microchannel biochip separator

A 3D simulation of the formation of primary platelet thrombi based on a hybrid computational model

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