A three‐component process for the synthesis of 2,3‐dihydroquinazolin‐4(1H)‐one derivatives using nanosized nickel aluminate spinel crystals as highly efficient catalysts

Abstract

NiAl2O4 spinel nanocrystals were synthesized as mesoporous catalysts and were fully characterized using Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray diffraction patterns (XRD), scanning electron microscopy (SEM), and Energy‐dispersive X‐ray spectroscopy (EDS). These nanocrystals catalyzed the synthesis of 2,3‐dihydroquinazolin‐4(1H)‐one derivatives via a one‐pot, three‐component condensation reaction of aromatic aldehydes, isatoic anhydride, and ammonium acetate or primary aromatic amine under microwave irradiation. By far, the most obvious advantages of the offered process are efficiency and recyclability of the catalyst as well as a significantly shorter reaction time.

Design, Regiospecific Green Synthesis, Chemical Computational Analysis, and Antimicrobial Evaluation of Novel Phthalazine Heterocycles

“…Wells with 6-mm diameter were punched in the agar and filled with the test samples to obtain different concentrations (viz. 15,25,35,45, and 55 μL) of the extract. For antibacterial assay, Ampicillin and Streptomycin were used as a standard and Nystatin as antifungal assay.…”

“…Some of O-alkyl-phthalazine derivatives were monitored in vitro for their antimicrobial effect, and the energy variance between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) plays a significant role in the electronic studies of these molecules by quantum chemical calculations that reflects the relation between delocalization, electron distribution, and chemical reactivity with kinetic stability of the compound [13][14][15][16][17]. Phthalazine derivatives were announced to acquire anticonvulsant [18], antitumor [19], antihypertensive, antithrombotic [20], antidiabetic [21], antitrypanosomal [22], anti-inflammatory [23], cardiotonic [24], and vasorelaxant [25] activities. Therefore, various strategies have been accounted for the synthesis of phthalazine derivatives [26][27][28][29][30][31].…”

Copper/Schiff‐base complex immobilized on amine functionalized silica mesoporous magnetic nanoparticles under solvent‐free condition: A facile and new avenue for the synthesis of thiazolidin‐4‐ones

“…The main synthetic routes for 1,3-thiazolidin-4-ones involve a threecomponent reaction between an amine, a carbonyl compound, and thioglycolic acid. [44][45][46] The newest methodology is synthesis of bis-thiazolidinones through multicomponent reaction of aldehydes, ethylenediamine, and thioglycolic acid using (a) nano-CdZr 4 (PO 4 ) 6 [47] and (b) chitosan-attached nano-CuFe 2 O 4 , [48] and synthesis of oxindole derivatives containing thiazolidinone using nano silica-bonded 5-n-propyl-octahydro-pyrimido [1,2-a] azepiniumchloride via a one-pot reaction of 5-oxoindolinylidene rhodanine-3-acetic acid derivatives, 2-aminothiophenol, and triphenyl phosphite. [49] Mesoporous silicas are inorganic materials formed by the condensation of sodium silicate or silicon alkoxides around an ordered surfactant used as template.…”

MNPs‐NHC6H4SO3H as high‐performance catalyst for the synthesis of 1,4‐diazepines containing tetrazole ring under microwave irradiation

“…[22,23] Despite the availability of these methods, there remains enough scope for an efficient and reusable catalyst with high catalytic activity to achieve such systems. In our continuing effort toward the development of efficient and environmentally benign magnetic nanocatalysts, [24][25][26][27] Figure S1. The XRD patterns indicate that the three products (Figure S1a-c) show similar diffraction peaks, indicating that the coating agent does not significantly affect the crystal structure of the magnetite nanoparticles.…”