A three-component one-pot procedure for the synthesis benzimidazolo-quinazolinone derivatives in the presence of chitosan-supported metal nanocomposite as a green and reusable catalyst

Abstract

A simple and convenient approach for the synthesis of tetraheterocyclic benzimidazolo [2,3-b]quinazolin-1-ones has been developed via a multicomponent reaction, which involves the condensation of 2-aminobenzimidazole, dimedone and various aldehydes using chitosan-supported metal nanocomposite as a green, reusable and environmentally benign catalyst system. Environmental friendly, recyclability, cost-effectiveness, easy workup and excellent yields are the major attributes of this one-pot procedure.

Recent advances in organo-nanocatalysis in the field of green organic synthesis

“…Since its development, this catalyst has been exploited as an efficient and recyclable organo-nanocatalyst in the synthesis of a number of heterocyclic compounds. [74][75][76][77][78][79][80][81][82][83][84] Scheme 2. Synthesis of 5,5-diarylhydantoins (3), diarylglycolurils (4) and their thio analogues.…”

An Efficient, Green, and Solvent‐free Multi‐component Synthesis of Benzimidazolo/Benzothiazolo Quinazolinone Derivatives Using Sc (OTf)3 Catalyst Under Controlled Microwave Irradiation

“…Several methods for the synthesis of quinazolinone derivatives have been quoted in the literature, for instance, by refluxing in DMF, H 6 P 2 W 18 O 62 ·18H 2 O, NH 2 SO 3 H, dodecylphosphonic acid, C 2 H 5 OH/SA, molecular iodine (I 2 ), ionic liquids, Nafion‐H catalyst in PEG‐400, chitosan‐supported ferrite nanocomposite, silica gel, FeF 3 , p ‐TsOH·H 2 O, Nano‐WO 3 ‐supported sulfonic acid, nanoporous silica (SBA‐Pr‐SO 3 H), succinimidinium hydrogensulfate [H‐Suc]HSO 4 , and [DABCO](SO 3 H) 2 Cl 2 . Every method has its own values and limitations.…”

Synthesis and Ways of Formation of Hydroxyphenyl Substituted Benz[4,5]imidazole-1,2,3,4,5,6- hexahydro[1,2-a]quinazolines

“…Синтез бензимидазолохиназолинов представлен в литературе [3,[5][6][7][8], но практически отсутствуют данные по построению систем, содержащих фенольные фрагменты, введение которых целесообразно для придания соединениям полезных свойств (дезинфицирующего, противогрибкового, для лечения заболеваний кожи, консервации лекарственных препаратов). Остаются открытыми вопросы путей синтеза данных соединений и изучения их фармакологической активности.…”