A Three‐Component Domino Reaction Enabled by Phase‐Transfer Catalysis for the Assembly of 3‐Thioquinoline‐2,5‐Diones
Lin Chen,
Tian‐Hao Zhu
Abstract:A three‐component phase‐transfer‐catalytic domino reaction involving cyclohexane‐1,3‐dione‐derived enaminones, 5‐alkenyl rhodanines, and haloalkanes has been developed. This protocol produces a wide range of 3‐thioquinoline‐2,5‐diones in yields of 52–81%. The construction of a C−S bond at the C‐3 position of the quinoline‐2,5‐dione framework expands its structural diversity. Studies into the reaction mechanism revealed that the reaction undergoes a conjugate addition, ammonolysis, elimination, and nucleophilic… Show more
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