A Thorough Systematic Review of Treatments for Atopic Eczema

Bigby, Michael

doi:10.1001/archderm.137.12.1635

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…Among these, 53(2.85%) patients, either visited the hospital with already developed ADRs, or developed ADR during their stay in the hospital. This shows a similar pattern of results, as reported by Michael Bigby 8 . Out of the total ADRs reported, 53% involved outpatients, and the remaining 47% were inpatients.…”

Section: Resultssupporting

confidence: 90%

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Study and evaluation of the various cutaneous adverse drug reactions in Kasturba hospital, Manipal

Ghosh¹,

Acharya²,

Rao³

2006

Indian J Pharm Sci

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The present study emphasizes on implementation of the adverse drug reaction reporting and monitoring system, in the Dermatology department of Kasturba Hospital, Manipal, by a clinical pharmacist, using different promotional activities. Documented adverse drug reactions were assessed and analyzed for incidence, purpose of visit, types, drug classes, individual drug causing adverse drug reactions, type of cutaneous reaction, and various predisposing factors. Management and outcome of the adverse drug reactions were also studied. Adverse drug reactions were also assessed for causality, using Naranjo's scale, severity, and preventability, using Hartwig et al. scale. Adverse drug reaction attributes to 77% of the hospital visit. Incidence of reported cutaneous adverse drug reactions, were 2.85%. Majority of the adverse drug reactions (96%) were of type B. Antibiotics (30%), were the common class of drugs, causing a cutaneous adverse drug reactions. Maximum number of adverse drug reactions were due to Acetaminophen, Amoxicillin, antitubercular drugs, and Phenytoin. Most of the adverse drug reactions were managed by withdrawal of drug (81%), and 58% patients were recovered from the reaction. Naranjos scale classifies, 29 as probable, 21 as possible, and 3 as definite adverse drug reactions. Most of the adverse drug reactions were of moderate severity, however 13 adverse drug reactions were severe. All the adverse drug reactions were probably preventable on extreme caution.

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Section: Resultssupporting

confidence: 90%

“…amoxicillin, which induced maculopapular rash, is well documented in medical literature, and there were very high reported incidences (5%) 2 . The second most common ADR, was erythematous skin lesion (8). This was more among patients treated with roxithromycin (2), and antiepileptics like phenytoin (1) and…”

Section: Resultsmentioning

confidence: 99%

Study and evaluation of the various cutaneous adverse drug reactions in Kasturba hospital, Manipal

Ghosh¹,

Acharya²,

Rao³

2006

Indian J Pharm Sci

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“…The importance of the histamine-independent pathway is evident. Patients with itch-related diseases such as atopic dermatitis, xeroderma, and psoriasis often complain that conventional antihistamine agents do not alleviate their severe difficult-to-tolerate itch [13] , [14] . Of course, this is because itch from these diseases are mostly histamine independent [15] , [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway

Lee

Kim

Shim

2018

Journal of Ginseng Research

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BackgroundIt was previously found that Korean Red Ginseng water extract (KRGE) inhibits the histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, we investigated whether KRGE inhibited another distinctive itch pathway induced by chloroquine (CQ); a representative histamine-independent pathway mediated by MrgprA3 and TRPA1.MethodsIntracellular calcium changes were measured by the calcium imaging technique in the HEK293T cells transfected with both MrgprA3 and TRPA1 (“MrgprA3/TRPA1”), and in primary culture of mouse dorsal root ganglia (DRGs). Mouse scratching behavior tests were performed to verify proposed antipruritic effects of KRGE and ginsenoside Rg3.ResultsCQ-induced Ca2+ influx was strongly inhibited by KRGE (10 μg/mL) in MrgprA3/TRPA1, and notably ginsenoside Rg3 dose-dependently suppressed CQ-induced Ca2+ influx in MrgprA3/TRPA1. Moreover, both KRGE (10 μg/mL) and Rg3 (100 μM) suppressed CQ-induced Ca2+ influx in primary culture of mouse DRGs, indicating that the inhibitory effect of KRGE was functional in peripheral sensory neurons. In vivo tests revealed that not only KRGE (100 mg) suppressed CQ-induced scratching in mice [bouts of scratching: 274.0 ± 51.47 (control) vs. 104.7 ± 17.39 (KRGE)], but also Rg3 (1.5 mg) oral administration significantly reduced CQ-induced scratching as well [bouts of scratching: 216.8 ± 33.73 (control) vs. 115.7 ± 20.94 (Rg3)].ConclusionThe present study verified that KRGE and Rg3 have a strong antipruritic effect against CQ-induced itch. Thus, KRGE is as a promising antipruritic agent that blocks both histamine-dependent and -independent itch at peripheral sensory neuronal levels.

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