A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS‐CoV‐2 vaccine

Yue, Lei; Xie, Tian; Yang, Ting; Zhou, Jian; Chen, Hongbo; Zhu, Hailian; Li, Hua; Xiang, Hong; Wang, Jie; Yang, Huijuan; Zhao, Hong; Wei, Xingchen; Zhang, Yuhao; Xie, Zhihui

doi:10.1002/jmv.27334

Cited by 61 publications

(73 citation statements)

References 12 publications

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“…Inactivated vaccines provoke an immune response by humoral immunity, therefore, they require multiple doses [ 15 ]. A third booster is encouraged in China to induce a stronger protection [ 16 ]. Commonly proposed mechanisms of inflammation may be induced by the adjuvants and have been classified as Shoenfeld syndrome typically occurring in patients with an autoimmune disorder, often accompanied by arthralgia and fatigue [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ocular Adverse Events after Inactivated COVID-19 Vaccination in Xiamen

Chen

et al. 2022

Vaccines

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Aims: To report potential vaccine-induced ocular adverse events following inactivated COVID-19 vaccination (Sinopharm and Sinovac). Methods: This case series took place at a tertiary referral center in the southeast of China (Xiamen Eye Center in Fujian Province) from February 2021 to July 2021. Patients who received the first dose of inactivated COVID-19 vaccine and developed vaccine-related ocular adverse events within 10 days were included. The diagnosis of vaccine-related ocular adverse events was guided by the World Health Organization causality assessment and the Naranjo criteria. Results: Ten eyes of seven patients (two male individuals) presenting with ocular complaints following COVID-19 vaccine were included in the study. The mean (SD) age was 41.4 (9.3) years (range, 30–55 years). The mean time of ocular adverse event manifestations was 4.9 days (range, 1–10 days). Three patients were diagnosed with Vogt–Koyanagi–Harada (VKH)-like uveitis, one with multifocal choroiditis, one with episcleritis, one with iritis, and one with acute idiopathic maculopathy. Two patients received the second dose of vaccine. One patient had exacerbation of VKH, and one patient had no symptoms. An aqueous humor analysis in three patients revealed elevated proinflammatory cytokines and negative virus copy. All the patients had transient ocular disturbance and responded well to steroids. No recurrence was noted during 6 months of follow-up. Conclusions: Potential ocular adverse events should be reported to increase the awareness of the health community for timely detection and proper treatment.

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Section: Discussionmentioning

confidence: 99%

Ocular Adverse Events after Inactivated COVID-19 Vaccination in Xiamen

Chen

et al. 2022

Vaccines

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“…Different types of COVID-19 vaccines including mRNA, viral vector, inactivated, and protein-based vaccines are used as boosters ( 33 , 36 , 38 – 41 ). In general, a booster dose can substantially increase NAb levels or their surrogate markers (e.g., anti-spike IgG) against SARS-CoV-2.…”

Section: Known Impact Of Sars-cov-2 Vaccine Booster Dosesmentioning

confidence: 99%

Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters

Burckhardt

Dennehy

Poon

et al. 2022

J Virol

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Waning vaccine-induced immunity coupled with the emergence of SARS-CoV-2 variants has led to increases in breakthrough infections, prompting consideration for vaccine booster doses. Boosters have been reported to be safe and increase SARS-CoV-2-specific neutralizing antibody levels, but how these doses impact the trajectory of the global pandemic and herd immunity is unknown. Information on immunology, epidemiology and equitable vaccine distribution should be considered when deciding the timing and eligibility for COVID-19 vaccine boosters.

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“…Recently, the need for a third dose of the COVID-19 vaccine has been discussed due to the threat of the B.1.617.2 (delta) variant and the need for the protection of immunocompromised individuals [13]. A three-dose regimen could reduce the risk of COVID-19 infection and reverse the waning of neutralizing antibodies after two doses of the vaccine [14][15][16]. However, the best timing of a third dose or boosting with heterologous vaccines is controversial [13,17,18].…”

Section: Introductionmentioning

confidence: 99%

Attitudes of Medical Students toward COVID-19 Vaccination: Who Is Willing to Receive a Third Dose of the Vaccine?

et al. 2021

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Medical students may come in contact with individuals infected with COVID-19 in their clinical rotations. A high level of acceptance of vaccination is needed for them to protect their health and the health of patients from this disease. The objectives of this study were to (1) obtain information on medical students’ attitudes toward COVID-19 vaccination, (2) assess factors associated with students’ attitudes, and (3) identify predictors of their willingness to receive a third dose of the COVID-19 vaccine. Using a cross-sectional design, we conducted a questionnaire survey of medical students in July 2021. For this survey, we employed a 15-item questionnaire specifically developed to assess the students’ attitudes toward COVID-19 vaccination. Of the 742 distributed questionnaires, 496 (294 males and 202 females) were completed. Among all the participants, 89.1% (442/496) received the second dose of the vaccine, and 90.7% (450/496) indicated that they would hypothetically receive the COVID-19 vaccine in the future. Furthermore, 84.5% (419/496) of all the participants were willing to receive a third dose of the vaccine. Regarding willingness to receive a third dose of the COVID-19 vaccine, multiple logistic regression models showed that students’ grade and their responses to Q1 (positive attitude toward vaccination), Q9 (belief in the protection offered by COVID-19 vaccination), Q10 (concern about the excessively rapid development of COVID-19 vaccines), Q12 (need for aspects of pre-pandemic life), and Q14 (concern about the sustainability of immunity) had significant associations with this outcome. Confidence in vaccines, relaxation of mobility restrictions, and concern about the sustainability of immunity motivate willingness to receive a third dose of the COVID-19 vaccine in medical students.

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A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS‐CoV‐2 vaccine

Cited by 61 publications

References 12 publications

Ocular Adverse Events after Inactivated COVID-19 Vaccination in Xiamen

Ocular Adverse Events after Inactivated COVID-19 Vaccination in Xiamen

Are COVID-19 Vaccine Boosters Needed? The Science behind Boosters

Attitudes of Medical Students toward COVID-19 Vaccination: Who Is Willing to Receive a Third Dose of the Vaccine?

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