A thin-film multichannel electrode for muscle recording and stimulation in neuroprosthetics applications

Muceli, Silvia; Poppendieck, Wigand; Hoffmann, Klaus‐Peter; Došen, Strahinja; Benito‐León, Julián; Barroso, Filipe O.; Pons, José L.; Farina, Dario

doi:10.1088/1741-2552/ab047a

Cited by 27 publications

(41 citation statements)

References 40 publications

(50 reference statements)

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“…The needle was removed after insertion, leaving the electrode within the muscle. These double-sided multichannel electrodes are built on a thin-film substrate of polyimide and embed twelve contacts for EMG recording and three contacts for electrical stimulation ( Figure 3) [16]. EMG data from each of the twelve recording points Fig.…”

Section: Stimulation Sessionsmentioning

confidence: 99%

“…For both types of stimulation, the maximum current was always below MT and below the safety limit. Stimulation frequency was set at 100 Hz [13], [24], with biphasic pulse width and maximum stimulation amplitude of 200 μs and 2.4 mA for IntraStim [16], and 400 μs and 5 mA for SurfStim [13], respectively.…”

Section: Stimulation Sessionsmentioning

confidence: 99%

“…Thereby, following the development of a novel thin-film multichannel electrode [16], the main goal of this study was to test the feasibility of using minimally invasive intramuscular electrodes, guided by adaptive EMG-based algorithms, to reduce wrist tremor in a sample of ET patients. Our second goal was to assess potential prolonged effects of this approach.…”

Section: Introductionmentioning

confidence: 99%

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Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

Pascual-Valdunciel¹,

González-Sánchez²,

Muceli³

et al. 2021

IEEE Trans. Biomed. Eng.

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This study proposes and clinically tests intramuscular electrical stimulation below motor threshold to achieve prolonged reduction of wrist flexion/extension tremor in Essential Tremor (ET) patients. The developed system consisted of an intramuscular thin-film electrode structure that included both stimulation and electromyography (EMG) recording electrodes, and a control algorithm for the timing of intramuscular stimulation based on EMG (closed-loop stimulation). Data were recorded from nine ET patients with wrist flexion/extension tremor recruited from the Gregorio Marañón Hospital (Madrid, Spain). Patients participated in two experimental sessions comprising: 1) sensory stimulation of wrist flexors/extensors via thin-film multichannel intramuscular electrodes; and 2) surface stimulation of the nerves innervating the same target muscles. For each session, four of these patients underwent random 60-s trials of two stimulation strategies for each target muscle: 1) selective and adaptive timely stimulation (SATS)-based on EMG of the antagonist muscle; and 2) continuous stimulation (CON) of target muscles. Two patients underwent SATS stimulation trials alone while the other three underwent CON stimulation trials alone in each session. Kinematics of wrist, elbow, and shoulder, together with clinical scales, were used to assess tremor before, right after, and 24 h after each session. Intramuscular SATS achieved, on average, 32% acute (during stimulation) tremor reduction on each trial, while continuous stimulation augmented tremorgenic activity. Furthermore, tremor reduction was significantly higher using intramuscular than surface stimulation. Prolonged reduction of tremor amplitude (24 h after the experiment) was

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Section: Stimulation Sessionsmentioning

confidence: 99%

Section: Stimulation Sessionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

Pascual-Valdunciel¹,

González-Sánchez²,

Muceli³

et al. 2021

IEEE Trans. Biomed. Eng.

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“…Among the review articles, ten studies reported the effects of peripheral electrical stimulation results on patients with ET [18][19][20][21][22][23][24][25][26][27] while ten studies reported on patients with PD [28][29][30][31][32][33][34][35][36][37] and seven studies included both patients with ET and patients with PD [16,17,[38][39][40][41][42]. In order to compare electrical stimulation strategies, some studies also included healthy volunteers that either mimicked tremorgenic activity during experimentation or were subject to artificially induced tremors for experimentation [31,38,41].…”

Section: Target Populationsmentioning

confidence: 99%

“…The rest of the articles analyzed in this review had sample sizes of 20 patients or less. In some cases, some articles can be considered case reports as Widjaja et al [19] or Muceli et al [36] only included one experimental subject, and Xu et al [31] only included two patients for experimentation, but were still included in this study due to the complete introduction, methods, results and discussion sections.…”

Section: Target Populationsmentioning

confidence: 99%

Peripheral electrical stimulation to reduce pathological tremor: a review

Pascual-Valdunciel

Hoo

Avrillon

et al. 2021

J NeuroEngineering Rehabil

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Interventions to reduce tremor in essential tremor (ET) and Parkinson’s disease (PD) clinical populations often utilize pharmacological or surgical therapies. However, there can be significant side effects, decline in effectiveness over time, or clinical contraindications for these interventions. Therefore, alternative approaches must be considered and developed. Some non-pharmacological strategies include assistive devices, orthoses and mechanical loading of the tremorgenic limb, while others propose peripheral electrical stimulation. Specifically, peripheral electrical stimulation encompasses strategies that activate motor and sensory pathways to evoke muscle contractions and impact sensorimotor function. Numerous studies report the efficacy of peripheral electrical stimulation to alter tremor generation, thereby opening new perspectives for both short- and long-term tremor reduction. Therefore, it is timely to explore this promising modality in a comprehensive review. In this review, we analyzed 27 studies that reported the use of peripheral electrical stimulation to reduce tremor and discuss various considerations regarding peripheral electrical stimulation: the stimulation strategies and parameters, electrodes, experimental designs, results, and mechanisms hypothesized to reduce tremor. From our review, we identified a high degree of disparity across studies with regard to stimulation patterns, experimental designs and methods of assessing tremor. Having standardized experimental methodology is a critical step in the field and is needed in order to accurately compare results across studies. With this review, we explore peripheral electrical stimulation as an intervention for tremor reduction, identify the limitations and benefits of the current state-of-the-art studies, and provide ideas to guide the development of novel approaches based on the neural circuitries and mechanical properties implied in tremor generation.

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Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

Tringides

Mooney

2022

Advanced Materials

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with the outermost layer of biological tissues, often spanning a significant surface area. Devices typically have multiple electrodes that aim to monitor and modulate cells and tissues in a minimally invasive manner, using biomaterials designed to evoke minimal inflammatory responses. Applications of Surface Electrode Arrays RecordingBecause surface electrode arrays can record a "snapshot" of the electrical activity at distinct locations, these arrays are useful to monitor the function of a tissue. Though the recordings are typically local field potentials, with electrodes that are small enough to modulate as little of a location as possible while still maintaining a sufficiently high conductivity, single units from individual cells have been reported. Clinically, these recordings are used to map the epicardial surface to identify instances, and potentially mechanisms, of chronic atrial fibrillation, [1] dysfunction of ventricular tachycardia caused by congenital defects, [2] and other abnormal conduction conditions in the cardiac system. Clinical electrocorticogram (ECoG) is used to identify similar functional changes on the cortical surface of the brain, most commonly to identify epileptic focal center(s), or detect seizure activity. [3][4][5][6][7] Other functional uses of ECoG include intraoperative monitoring during tumor resection. [8] A surgeon can ask a patient to perform an activity such as a speech and then identify and avoid the active cortical regions during surgery, to avoid major disruptions to the patient quality of life. StimulationInstead of passively monitoring electrical activity, multielectrode surface arrays can provide electrical current to the underlying tissue and induce a desired excitatory or inhibitory response. The applications for stimulating surface electrode arrays are often therapeutic and include implantable pacemakers, which restore a normal cardiac rhythm by providing external and overriding cues to the cardiomyocytes responsible for establishing a sinus rhythm. [9] Pulses delivered to specific regions of the spinal cord are used to manage chronic pain, [10][11][12] and more recently as a therapy to promote neuronal plasticity in Surface electrode arrays are mainly fabricated from rigid or elastic materials, and precisely manipulated ductile metal films, which offer limited stretchability. However, the living tissues to which they are applied are nonlinear viscoelastic materials, which can undergo significant mechanical deformation in dynamic biological environments. Further, the same arrays and compositions are often repurposed for vastly different tissues rather than optimizing the materials and mechanical properties of the implant for the target application. By first characterizing the desired biological environment, and then designing a technology for a particular organ, surface electrode arrays may be more conformable, and offer better interfaces to tissues while causing less damage. Here, the various materials used in each component of a surface electrode array are first r...

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A thin-film multichannel electrode for muscle recording and stimulation in neuroprosthetics applications

Cited by 27 publications

References 40 publications

Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

Peripheral electrical stimulation to reduce pathological tremor: a review

Materials for Implantable Surface Electrode Arrays: Current Status and Future Directions

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